Title |
P85 regulates neuronal migration through affecting neuronal morphology during mouse corticogenesis
|
---|---|
Published in |
Cell and Tissue Research, November 2017
|
DOI | 10.1007/s00441-017-2707-8 |
Pubmed ID | |
Authors |
Xinran Cheng, Kaikai Li, MengMeng Liu, Xinde Hu, Mingrui Xu, Runchuan Yan, Shanting Zhao |
Abstract |
In mammalian developing embryonic cortex, projection neurons migrate from the ventricular zone to the cortical plate, guided by radial glial cells with a transformation between bipolar and multipolar morphology. Previous studies have demonstrated that the PI3K-Akt-mTOR signal plays a critical role in brain development. However, the function of P85 in cortical development is still unclear. In the present study, we found that overexpression of P85 impaired cortical neuronal migration. Using in utero electroporation, we revealed that the length of the leading process in P85 overexpressed neurons became shorter than that in the control group but with more branches. Using markers for new-born neurons, we further found that overexpression of P85 did not affect the ultimate fate of these cortical neurons. These findings indicated that the P85 subunit plays an essential role in neuronal migration and neuronal morphology during mouse corticogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 18% |
Student > Ph. D. Student | 2 | 18% |
Professor | 1 | 9% |
Student > Master | 1 | 9% |
Student > Postgraduate | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 27% |
Biochemistry, Genetics and Molecular Biology | 2 | 18% |
Agricultural and Biological Sciences | 1 | 9% |
Engineering | 1 | 9% |
Unknown | 4 | 36% |