Title |
Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their association with oral squamous cell carcinoma (OSCC) in northern India
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Published in |
Tumor Biology, November 2014
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DOI | 10.1007/s13277-014-2538-0 |
Pubmed ID | |
Authors |
Prithvi Kumar Singh, Mohd. Kaleem Ahmad, Vijay Kumar, Syed Rizwan Hussain, Rajni Gupta, Amita Jain, Abbas Ali Mahdi, Jaishri Bogra, Girish Chandra |
Abstract |
Interleukin-18 (IL-18) is one of the immunomodulatory cytokines that plays an important role in cellular functions against tumor development and progression. IL-18 (-607) C/A and (-0137) G/C gene promoter polymorphisms and their haplotypes variants are associated with risk of various cancers. We evaluated a possible association of IL-18 (-607) C/A and (-137) G/C gene promoter polymorphisms in the susceptibility to oral squamous cell carcinoma (OSCC). A total number of 272 patients with OSCC and 185 healthy volunteers were genotyped for the IL-18 (-607) C/A and (-137) G/C polymorphism. Polymorphism variants were examined by using tetra-primer amplification refractory mutation system (T-ARMS). Genotype frequencies were evaluated by chi-square test and odds ratio (OR) relative risk. IL-18 (-137) G/C gene polymorphism was significantly associated with the risk of OSCC as compared to healthy volunteers (genotype GG vs GC: OR 2.238; 95 % CI 1.455-3.441; p = 0.0003 and allele G vs C: OR 1.984; 95 % CI 1.335-2.947; p = 0.0007). The genotype and allele frequencies of the IL-18 promoter -607 C/A polymorphism in OSCC patients were not significantly different than that in healthy controls (p > 0.05). Our results suggest that IL-18 -137 G/C polymorphism is significantly associated with the progression of oral cancer but -607 C/A polymorphism is not associated with this. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 20% |
Student > Postgraduate | 3 | 15% |
Student > Ph. D. Student | 3 | 15% |
Other | 2 | 10% |
Professor | 1 | 5% |
Other | 3 | 15% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 35% |
Agricultural and Biological Sciences | 4 | 20% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Immunology and Microbiology | 1 | 5% |
Environmental Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 25% |