| Title |
Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease
|
|---|---|
| Published in |
GeroScience, November 2014
|
| DOI | 10.1007/s11357-014-9729-x |
| Pubmed ID | |
| Authors |
Valquiria Bueno, Osvaldo Augusto Sant’Anna, Janet M Lord |
| Abstract |
Infections, cancer and autoimmune diseases occur more frequently in the elderly, and although many factors contribute to this, the age-related remodelling of the immune system, termed immunosenescence, plays a major role. Over the last two decades, studies have evaluated the effect of ageing on both the adaptive and innate arms of the immune system and demonstrated compromised function in several cells including lymphocytes (naïve, effector and memory), regulatory T and B cells, monocytes, neutrophils and NK cells. In addition, a well-documented feature of ageing is the increase in systemic inflammatory status (inflammageing), with raised serum levels of IL6, TNFα and CRP as well as reduced IL10. Recently, myeloid-derived suppressor cells have been the focus of many reports as these cells show immunosuppressive properties and are present in higher frequency during infections, cancer and autoimmunity. Importantly, there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans. In this review, we discuss the current literature on myeloid-derived suppressor cells, their possible role in altered immune function in the elderly, and whether it may be possible to manipulate these cells to alleviate age-related immune dysfunction. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 75 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 28% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 7 | 9% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 5 | 7% |
| Other | 9 | 12% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 15 | 20% |
| Biochemistry, Genetics and Molecular Biology | 13 | 17% |
| Medicine and Dentistry | 12 | 16% |
| Agricultural and Biological Sciences | 7 | 9% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 21 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2015.
All research outputs
#22,759,802
of 25,374,647 outputs
Outputs from GeroScience
#1,512
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Outputs of similar age
#215,690
of 253,327 outputs
Outputs of similar age from GeroScience
#16
of 16 outputs
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