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Genetic characterization of H5N1 influenza A viruses isolated from zoo tigers in Thailand

Overview of attention for article published in Virology, September 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
2 news outlets
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
86 Dimensions

Readers on

mendeley
63 Mendeley
citeulike
1 CiteULike
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Title
Genetic characterization of H5N1 influenza A viruses isolated from zoo tigers in Thailand
Published in
Virology, September 2005
DOI 10.1016/j.virol.2005.08.032
Pubmed ID
Authors

Alongkorn Amonsin, Sunchai Payungporn, Apiradee Theamboonlers, Roongroje Thanawongnuwech, Sanipa Suradhat, Nuananong Pariyothorn, Rachod Tantilertcharoen, Sudarat Damrongwantanapokin, Chantanee Buranathai, Arunee Chaisingh, Thaweesak Songserm, Yong Poovorawan

Abstract

The H5N1 avian influenza virus outbreak among zoo tigers in mid-October 2004, with 45 animals dead, indicated that the avian influenza virus could cause lethal infection in a large mammalian species apart from humans. In this outbreak investigation, six H5N1 isolates were identified and two isolates (A/Tiger/Thailand/CU-T3/04 and A/Tiger/Thailand/CU-T7/04) were selected for whole genome analysis. Phylogenetic analysis of the 8 gene segments showed that the viruses clustered within the lineage of H5N1 avian isolates from Thailand and Vietnam. The hemagglutinin (HA) gene of the viruses displayed polybasic amino acids at the cleavage site, identical to those of the 2004 H5N1 isolates, which by definition are highly pathogenic avian influenza (HPAI). In addition, sequence analyses revealed that the viruses isolated from tigers harbored few genetic changes compared with the viruses having infected chicken, humans, tigers and a leopard isolated from the early 2004 H5N1 outbreaks. Sequence analyses also showed that the tiger H5N1 isolated in October 2004 was more closely related to the chicken H5N1 isolated in July than that from January. Interestingly, all the 6 tiger H5N1 isolates contained a lysine substitution at position 627 of the PB2 protein similar to the human, but distinct from the original avian isolates.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Australia 1 2%
India 1 2%
Saudi Arabia 1 2%
Denmark 1 2%
United States 1 2%
Unknown 57 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 24%
Student > Ph. D. Student 9 14%
Student > Master 7 11%
Professor 5 8%
Student > Bachelor 3 5%
Other 11 17%
Unknown 13 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 44%
Medicine and Dentistry 10 16%
Immunology and Microbiology 4 6%
Veterinary Science and Veterinary Medicine 3 5%
Computer Science 1 2%
Other 6 10%
Unknown 11 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2014.
All research outputs
#1,981,277
of 25,374,917 outputs
Outputs from Virology
#231
of 9,498 outputs
Outputs of similar age
#3,172
of 70,160 outputs
Outputs of similar age from Virology
#2
of 58 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,498 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,160 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.