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Anatomical and physiological basis of continuous spike–wave of sleep syndrome after early thalamic lesions

Overview of attention for article published in Epilepsy & Behavior, November 2017
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Title
Anatomical and physiological basis of continuous spike–wave of sleep syndrome after early thalamic lesions
Published in
Epilepsy & Behavior, November 2017
DOI 10.1016/j.yebeh.2017.08.027
Pubmed ID
Authors

Alberto Leal, Eulália Calado, José P. Vieira, Carla Mendonça, José C. Ferreira, Hugo Ferreira, Daniel Carvalho, Fátima Furtado, Roseli Gomes, José P. Monteiro

Abstract

Early neonatal thalamic lesions account for about 14% of continuous spike-wave of sleep (CSWS) syndrome, representing the most common etiology in this epileptic encephalopathy in children, and promise useful insights into the pathophysiology of the disease. We describe nine patients with unilateral neonatal thalamic lesions which progressed to CSWS. Longitudinal whole-night and high-density electroencephalograms (EEGs) were performed, as well as detailed imaging and clinical evaluation. Visual evoked potentials were used to probe cortical excitability. Thalamic volume loss ranged from 19% to 94%, predominantly on medial and dorsal nuclei and sparing the ventral thalamus. Lesions produced white matter loss and ventricle enlargement on the same hemisphere, which in four patients was associated with selective loss of thalamic-cortical fibers. Cortical thickness quantification failed to reveal hemispheric asymmetries. Impact on EEG rhythms was mild, with a volume-loss-related decrease in alpha power and preservation of sleep spindles. The sleep continuous spiking was lateralized to the hemisphere with the lesion. Visual cortex stimulation in five patients with posterior cortex spiking revealed an abnormal frequency-dependent excitability at 10-20Hz on the side of the lesion. Unilateral selective thalamic-cortical disconnection is a common feature in our patients and is associated with both a focal pattern of CSWS and a pathological type of frequency-dependent excitability (peak: 10-20Hz). We propose that this excitability represents an abnormal synaptic plasticity previously described as the augmenting response. This synaptic plasticity has been described as absent in the corticocortical interactions in healthy experimental animals, emerging after ablation of the thalamus and producing a frequency-dependent potentiation with a peak at 10-20Hz. Because this response is potentiated by sleep states of reduced brainstem activation and by appropriate stimulating rhythms, such as sleep spindles, the simultaneous occurrence of these two factors in nonrapid-eye-movement sleep is proposed as an explanation for CSWS in our patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 16%
Researcher 6 11%
Student > Bachelor 6 11%
Student > Master 6 11%
Student > Doctoral Student 5 9%
Other 10 18%
Unknown 15 26%
Readers by discipline Count As %
Medicine and Dentistry 11 19%
Neuroscience 10 18%
Psychology 9 16%
Biochemistry, Genetics and Molecular Biology 1 2%
Nursing and Health Professions 1 2%
Other 2 4%
Unknown 23 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2017.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Epilepsy & Behavior
#2,762
of 4,611 outputs
Outputs of similar age
#216,092
of 338,252 outputs
Outputs of similar age from Epilepsy & Behavior
#47
of 94 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,611 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,252 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.