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A role for bacterial urease in gut dysbiosis and Crohn’s disease

Overview of attention for article published in Science Translational Medicine, November 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
26 news outlets
blogs
3 blogs
twitter
62 X users
facebook
2 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor
video
1 YouTube creator

Citations

dimensions_citation
163 Dimensions

Readers on

mendeley
290 Mendeley
citeulike
1 CiteULike
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Title
A role for bacterial urease in gut dysbiosis and Crohn’s disease
Published in
Science Translational Medicine, November 2017
DOI 10.1126/scitranslmed.aah6888
Pubmed ID
Authors

Josephine Ni, Ting-Chin David Shen, Eric Z Chen, Kyle Bittinger, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S Friedman, Lillian Chau, Andrew Lin, Ilana Nissim, Justin Scott, Abigail Lauder, Christopher Hoffmann, Gloriany Rivas, Lindsey Albenberg, Robert N Baldassano, Jonathan Braun, Ramnik J Xavier, Clary B Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D Bushman, James D Lewis, Gary D Wu

Abstract

Gut dysbiosis during inflammatory bowel disease involves alterations in the gut microbiota associated with inflammation of the host gut. We used a combination of shotgun metagenomic sequencing and metabolomics to analyze fecal samples from pediatric patients with Crohn's disease and found an association between disease severity, gut dysbiosis, and bacterial production of free amino acids. Nitrogen flux studies using (15)N in mice showed that activity of bacterial urease, an enzyme that releases ammonia by hydrolysis of host urea, led to the transfer of murine host-derived nitrogen to the gut microbiota where it was used for amino acid synthesis. Inoculation of a conventional murine host (pretreated with antibiotics and polyethylene glycol) with commensal Escherichia coli engineered to express urease led to dysbiosis of the gut microbiota, resulting in a predominance of Proteobacteria species. This was associated with a worsening of immune-mediated colitis in these animals. A potential role for altered urease expression and nitrogen flux in the development of gut dysbiosis suggests that bacterial urease may be a potential therapeutic target for inflammatory bowel diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 62 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 290 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 290 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 57 20%
Student > Ph. D. Student 41 14%
Student > Master 31 11%
Student > Bachelor 21 7%
Other 18 6%
Other 49 17%
Unknown 73 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 52 18%
Agricultural and Biological Sciences 42 14%
Immunology and Microbiology 40 14%
Medicine and Dentistry 22 8%
Chemistry 10 3%
Other 37 13%
Unknown 87 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 242. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2022.
All research outputs
#154,659
of 25,382,440 outputs
Outputs from Science Translational Medicine
#485
of 5,434 outputs
Outputs of similar age
#3,127
of 335,862 outputs
Outputs of similar age from Science Translational Medicine
#13
of 111 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 86.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.