| Title |
Diagnostic Approaches for Salivary Gland Tumors with Secretory and Microcystic Features
|
|---|---|
| Published in |
Head and Neck Pathology, November 2017
|
| DOI | 10.1007/s12105-017-0864-4 |
| Pubmed ID | |
| Authors |
Ha Young Woo, Eun Chang Choi, Sun Och Yoon |
| Abstract |
Secretory carcinoma (SC) of the salivary gland is a new entity that shares the unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 fusion gene with its breast counterpart. Before identification of SC of the salivary gland, it was most frequently diagnosed as acinic cell carcinoma (AciCC). We retrospectively reviewed our own database of salivary gland tumors harboring microcystic and papillary architecture and/or secretory features that were originally diagnosed as AciCC. We selected nine cases of AciCC showing diffuse S-100 expression on immunohistochemistry (IHC). A recently diagnosed case of SC was included in the study as a reference sample. We performed IHC of S-100 and mammaglobin and ETV6 gene fluorescence in situ hybridization (FISH) in all cases. Seven cases were positive for both S-100 and mammaglobin, while five of the seven (71.4%) demonstrated ETV6 gene translocation by FISH. In the cases which did not co-express either S-100 or mammaglobin on IHC, ETV6 gene rearrangement was not shown on FISH. In conclusion, if a salivary gland tumor has morphologic features of SC with co-expression of S-100 and mammaglobin, ETV6 FISH can be performed to confirm the diagnosis of SC of the salivary gland. |
X Demographics
The data shown below were collected from the profiles of 75 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 19% |
| India | 7 | 9% |
| Spain | 3 | 4% |
| Kenya | 2 | 3% |
| Mexico | 2 | 3% |
| Venezuela, Bolivarian Republic of | 2 | 3% |
| Turkey | 2 | 3% |
| China | 1 | 1% |
| Chile | 1 | 1% |
| Other | 13 | 17% |
| Unknown | 28 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 48 | 64% |
| Practitioners (doctors, other healthcare professionals) | 12 | 16% |
| Scientists | 10 | 13% |
| Science communicators (journalists, bloggers, editors) | 4 | 5% |
| Unknown | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 4 | 20% |
| Student > Master | 3 | 15% |
| Student > Bachelor | 2 | 10% |
| Researcher | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Other | 1 | 5% |
| Unknown | 6 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 50% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Unspecified | 1 | 5% |
| Unknown | 8 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2022.
All research outputs
#888,849
of 25,373,627 outputs
Outputs from Head and Neck Pathology
#13
of 1,007 outputs
Outputs of similar age
#18,129
of 336,098 outputs
Outputs of similar age from Head and Neck Pathology
#1
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,007 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.