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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing
|
|---|---|
| Published in |
eLife, November 2014
|
| DOI | 10.7554/elife.03790 |
| Pubmed ID | |
| Authors |
Annina Denoth-Lippuner, Marek Konrad Krzyzanowski, Catherine Stober, Yves Barral |
| Abstract |
In eukaryotes, intra-chromosomal recombination generates DNA circles, but little is known about how cells react to them. In yeast, partitioning of such circles to the mother cell at mitosis ensures their loss from the population but promotes replicative ageing. Nevertheless, the mechanisms of partitioning are debated. In this study, we show that the SAGA complex mediates the interaction of non-chromosomal DNA circles with nuclear pore complexes (NPCs) and thereby promotes their confinement in the mother cell. Reciprocally, this causes retention and accumulation of NPCs, which affects the organization of ageing nuclei. Thus, SAGA prevents the spreading of DNA circles by linking them to NPCs, but unavoidably causes accumulation of circles and NPCs in the mother cell, and thereby promotes ageing. Together, our data provide a unifying model for the asymmetric segregation of DNA circles and how age affects nuclear organization. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 87 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 20% |
| Researcher | 18 | 20% |
| Student > Master | 11 | 12% |
| Student > Bachelor | 8 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 13 | 15% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 39 | 44% |
| Agricultural and Biological Sciences | 28 | 31% |
| Business, Management and Accounting | 3 | 3% |
| Immunology and Microbiology | 2 | 2% |
| Medicine and Dentistry | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 15 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2022.
All research outputs
#13,812,185
of 23,800,390 outputs
Outputs from eLife
#11,922
of 14,485 outputs
Outputs of similar age
#178,122
of 365,004 outputs
Outputs of similar age from eLife
#130
of 184 outputs
Altmetric has tracked 23,800,390 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,485 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.9. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,004 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 184 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.