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Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals

Overview of attention for article published in Immunology, January 2018
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Title
Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals
Published in
Immunology, January 2018
DOI 10.1111/imm.12864
Pubmed ID
Authors

Thitiya Luetragoon, Lars E. Rutqvist, Orathai Tangvarasittichai, Bengt‐Åke Andersson, Sture Löfgren, Kanchana Usuwanthim, Nongnit L. Lewin

Abstract

Cigarette smoke contains toxic and carcinogenic substances that contribute to the development of cancer and various diseases. Genetic variation might be important because not all smokers develop smoking-related disease. The current study addressed the possible interactions among selected single nucleotide polymorphisms (SNPs) in genes related to systemic inflammation, smoking status, the levels of circulating immune response cells and plasma biomarkers of systemic inflammation. Sixty-four healthy blood donors were recruited, of whom 31 were current smokers and 33 were never-users of tobacco products, references. Compared to references, the smokers showed significantly increased levels of circulating total white blood cells, lymphocytes, monocytes, neutrophils, basophils, and C-reactive protein (CRP). Smokers also more frequently exhibited circulating cell phenotypes that are associated with an immunocompromised state: CD8dim cells in the lymphocyte group, CD13(+) 11(+) , CD13(+) 14(+) , CD13(+) 56(+) cells in the monocyte group, and CD13(+) 11(+) , CD13(+) 56(+) cells in the neutrophil group. We observed an interaction among SNPs, smoking status and some of the studied biomarkers. The average plasma CRP level was significantly higher among the smokers, with the highest level found among those with the CRP rs1800947 CC genotype. Additionally, an increased CD8(+) GZB(+) cells in the CD8dim group were found among smokers with the GZB rs8192917 AA genotype. Thus, smoking appears to be associated with systemic inflammation and increased levels of circulating immunosuppressive cells. The extent of these effects was associated with SNPs among the smokers. This observation may contribute to a better understanding of the genetic susceptibility of smoking-related disease and the variations observed in clinical outcomes. This article is protected by copyright. All rights reserved.

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The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 17%
Other 3 13%
Researcher 3 13%
Student > Postgraduate 2 8%
Professor > Associate Professor 2 8%
Other 1 4%
Unknown 9 38%
Readers by discipline Count As %
Medicine and Dentistry 6 25%
Biochemistry, Genetics and Molecular Biology 3 13%
Immunology and Microbiology 2 8%
Agricultural and Biological Sciences 2 8%
Environmental Science 1 4%
Other 2 8%
Unknown 8 33%