| Title |
Genetics of Post-Traumatic Stress Disorder: Review and Recommendations for Genome-Wide Association Studies
|
|---|---|
| Published in |
Current Psychiatry Reports, June 2010
|
| DOI | 10.1007/s11920-010-0126-6 |
| Pubmed ID | |
| Authors |
Marilyn C. Cornelis, Nicole R. Nugent, Ananda B. Amstadter, Karestan C. Koenen |
| Abstract |
Post-traumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder that constitutes a major health care burden. Despite evidence supporting a genetic predisposition to PTSD, the precise genetic loci remain unclear. Herein we review the current state and limitations of genetic research on PTSD. Although recent years have seen an exponential increase in the number of studies examining the influence of candidate genes on PTSD diagnosis and symptomatology, most studies have been characterized by relatively low rates of PTSD, with apparent inconsistencies in gene associations linked to marked differences in methodology. We further discuss how current advances in the genetics field can be applied to studies of PTSD, emphasizing the need to adapt a genome-wide approach that facilitates discovery rather than hypothesis testing. Genome-wide association studies offer the best opportunity to identify novel "true" risk variants for the disorder that in turn has the potential to inform our understanding of PTSD etiology. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Spain | 1 | 13% |
| Ireland | 1 | 13% |
| Japan | 1 | 13% |
| Canada | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Germany | 2 | <1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 209 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 37 | 17% |
| Student > Ph. D. Student | 35 | 16% |
| Researcher | 33 | 15% |
| Student > Master | 24 | 11% |
| Student > Postgraduate | 17 | 8% |
| Other | 45 | 21% |
| Unknown | 27 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 63 | 29% |
| Medicine and Dentistry | 42 | 19% |
| Agricultural and Biological Sciences | 22 | 10% |
| Neuroscience | 21 | 10% |
| Biochemistry, Genetics and Molecular Biology | 19 | 9% |
| Other | 19 | 9% |
| Unknown | 32 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2023.
All research outputs
#1,307,161
of 25,247,084 outputs
Outputs from Current Psychiatry Reports
#155
of 1,273 outputs
Outputs of similar age
#4,007
of 102,349 outputs
Outputs of similar age from Current Psychiatry Reports
#1
of 13 outputs
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So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.7. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.