| Title |
Apparent diffusion coefficient of vertebral haemangiomas allows differentiation from malignant focal deposits in whole-body diffusion-weighted MRI
|
|---|---|
| Published in |
European Radiology, November 2017
|
| DOI | 10.1007/s00330-017-5079-2 |
| Pubmed ID | |
| Authors |
Jessica M. Winfield, Gabriele Poillucci, Matthew D. Blackledge, David J. Collins, Vallari Shah, Nina Tunariu, Martin F. Kaiser, Christina Messiou |
| Abstract |
The aim of this study was to identify apparent diffusion coefficient (ADC) values for typical haemangiomas in the spine and to compare them with active malignant focal deposits. This was a retrospective single-institution study. Whole-body magnetic resonance imaging (MRI) scans of 106 successive patients with active multiple myeloma, metastatic prostate or breast cancer were analysed. ADC values of typical vertebral haemangiomas and malignant focal deposits were recorded. The ADC of haemangiomas (72 ROIs, median ADC 1,085×10(-6)mm(2)s(-1), interquartile range 927-1,295×10(-6)mm(2)s(-1)) was significantly higher than the ADC of malignant focal deposits (97 ROIs, median ADC 682×10(-6)mm(2)s(-1), interquartile range 583-781×10(-6)mm(2)s(-1)) with a p-value < 10(-6). Receiver operating characteristic (ROC) analysis produced an area under the curve of 0.93. An ADC threshold of 872×10(-6)mm(2)s(-1) separated haemangiomas from malignant focal deposits with a sensitivity of 84.7 % and specificity of 91.8 %. ADC values of classical vertebral haemangiomas are significantly higher than malignant focal deposits. The high ADC of vertebral haemangiomas allows them to be distinguished visually and quantitatively from active sites of disease, which show restricted diffusion. • Whole-body diffusion-weighted MRI is becoming widely used in myeloma and bone metastases. • ADC values of vertebral haemangiomas are significantly higher than malignant focal deposits. • High ADCs of haemangiomas allows them to be distinguished from active disease. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 8 | 17% |
| Student > Postgraduate | 7 | 15% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 3 | 6% |
| Student > Master | 3 | 6% |
| Other | 8 | 17% |
| Unknown | 13 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 47% |
| Engineering | 2 | 4% |
| Neuroscience | 2 | 4% |
| Physics and Astronomy | 2 | 4% |
| Nursing and Health Professions | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 14 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2017.
All research outputs
#17,920,654
of 23,008,860 outputs
Outputs from European Radiology
#2,839
of 4,169 outputs
Outputs of similar age
#233,197
of 326,002 outputs
Outputs of similar age from European Radiology
#42
of 66 outputs
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