| Title |
Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment
|
|---|---|
| Published in |
Journal of Neuro-Oncology, September 2012
|
| DOI | 10.1007/s11060-012-0973-6 |
| Pubmed ID | |
| Authors |
Rintaro Hashizume, Ivan Smirnov, Sharon Liu, Joanna J. Phillips, Jeanette Hyer, Tracy R. McKnight, Michael Wendland, Michael Prados, Anu Banerjee, Theodore Nicolaides, Sabine Mueller, Charles D. James, Nalin Gupta |
| Abstract |
Diffuse intrinsic pontine gliomas arise almost exclusively in children, and despite advances in treatment, the majority of patients die within 2 years after initial diagnosis. Because of their infiltrative nature and anatomic location in an eloquent area of the brain, most pontine gliomas are treated without a surgical biopsy. The corresponding lack of tissue samples has resulted in a limited understanding of the underlying genetic and molecular biologic abnormalities associated with pontine gliomas, and is a substantial obstacle for the preclinical testing of targeted therapeutic agents for these tumors. We have established a human glioma cell line that originated from surgical biopsy performed on a patient with a pontine glioma. To insure sustainable in vitro propagation, tumor cells were modified with hTERT (human telomerase ribonucleoprotein reverse transcriptase), and with a luciferase reporter to enable non-invasive bioluminescence imaging. The hTERT modified cells are tumorigenic in athymic rodents, and produce brainstem tumors that recapitulate the infiltrative growth of brainstem gliomas in patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 78 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 20% |
| Student > Ph. D. Student | 12 | 15% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 6 | 8% |
| Other | 6 | 8% |
| Other | 12 | 15% |
| Unknown | 20 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 20% |
| Agricultural and Biological Sciences | 14 | 18% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Neuroscience | 8 | 10% |
| Engineering | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 22 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2022.
All research outputs
#2,830,094
of 25,846,867 outputs
Outputs from Journal of Neuro-Oncology
#180
of 3,297 outputs
Outputs of similar age
#19,201
of 189,963 outputs
Outputs of similar age from Journal of Neuro-Oncology
#3
of 18 outputs
Altmetric has tracked 25,846,867 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,297 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.