| Title |
Does Disruption of Circadian Rhythms Contribute to Beta-Cell Failure in Type 2 Diabetes?
|
|---|---|
| Published in |
Current Diabetes Reports, February 2014
|
| DOI | 10.1007/s11892-014-0474-4 |
| Pubmed ID | |
| Authors |
Kuntol Rakshit, Anthony P. Thomas, Aleksey V. Matveyenko |
| Abstract |
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining greater appreciation as a risk factor for T2DM is the disruption of circadian rhythms (eg, shift-work and sleep loss). In recent years, circadian disruption has become increasingly prevalent in modern societies and consistently shown to augment T2DM susceptibility (partly mediated through its effects on pancreatic beta-cells). Since beta-cell failure is essential for development of T2DM, we will review current work from epidemiologic, clinical, and animal studies designed to gain insights into the molecular and physiological mechanisms underlying the predisposition to beta-cell failure associated with circadian disruption. Elucidating the role of circadian clocks in regulating beta-cell health will add to our understanding of T2DM pathophysiology and may contribute to the development of novel therapeutic and preventative approaches. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 20% |
| United States | 1 | 20% |
| Canada | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 11% |
| Researcher | 3 | 8% |
| Student > Ph. D. Student | 2 | 5% |
| Student > Master | 2 | 5% |
| Student > Doctoral Student | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 23 | 62% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 4 | 11% |
| Agricultural and Biological Sciences | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Sports and Recreations | 1 | 3% |
| Neuroscience | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 24 | 65% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2023.
All research outputs
#6,647,179
of 23,485,296 outputs
Outputs from Current Diabetes Reports
#339
of 1,022 outputs
Outputs of similar age
#62,784
of 224,307 outputs
Outputs of similar age from Current Diabetes Reports
#7
of 27 outputs
Altmetric has tracked 23,485,296 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,022 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.