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X Demographics
Mendeley readers
Attention Score in Context
| Title |
PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer
|
|---|---|
| Published in |
Nanomedicine, November 2014
|
| DOI | 10.2217/nnm.14.122 |
| Pubmed ID | |
| Authors |
Brian Wan-Chi Tse, Gary J Cowin, Carolina Soekmadji, Lidija Jovanovic, Raja S Vasireddy, Ming-Tat Ling, Aparajita Khatri, Tianqing Liu, Benjamin Thierry, Pamela J Russell |
| Abstract |
Aim: To evaluate the potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of PSMA, to enhance MRI of prostate cancer. Materials & methods: Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2 h and 24 h after intravenous injection of J591-MNPs, or non-targeting MNPs. Results & conclusion: In vitro, MNPs did not affect prostate cancer cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. Magnetic resonance contrast of tumors was increased in vivo using PSMA-targeting MNPs, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance magnetic resonance detection/localization of prostate cancer. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 84 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 22% |
| Student > Ph. D. Student | 15 | 17% |
| Student > Bachelor | 12 | 14% |
| Student > Master | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Other | 9 | 10% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 15% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Medicine and Dentistry | 9 | 10% |
| Agricultural and Biological Sciences | 8 | 9% |
| Engineering | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 25 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#7,007,654
of 25,608,265 outputs
Outputs from Nanomedicine
#299
of 1,295 outputs
Outputs of similar age
#88,453
of 371,225 outputs
Outputs of similar age from Nanomedicine
#9
of 32 outputs
Altmetric has tracked 25,608,265 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,295 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.