| Title |
The nucleolus: a model for the organization of nuclear functions
|
|---|---|
| Published in |
Histochemistry and Cell Biology, July 2006
|
| DOI | 10.1007/s00418-006-0212-3 |
| Pubmed ID | |
| Authors |
Danièle Hernandez-Verdun |
| Abstract |
Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus, ribosomal RNAs (rRNAs) are synthesized, processed and assembled with ribosomal proteins. The size and organization of the nucleolus are directly related to ribosome production. The organization of the nucleolus reveals the functional compartmentation of the nucleolar machineries that depends on nucleolar activity. When this activity is blocked, disrupted or impossible, the nucleolar proteins have the capacity to interact independently of the processing activity. In addition, nucleoli are dynamic structures in which nucleolar proteins rapidly associate and dissociate with nucleolar components in continuous exchanges with the nucleoplasm. At the time of nucleolar assembly, the processing machineries are recruited in a regulated manner in time and space, controlled by different kinases and form intermediate structures, the prenucleolar bodies. The participation of stable pre-rRNAs in nucleolar assembly was demonstrated after mitosis and during development but this is an intriguing observation since the role of these pre-rRNAs is presently unknown. A brief report on the nucleolus and diseases is proposed as well as of nucleolar functions different from ribosome biogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| France | 1 | 1% |
| Unknown | 89 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 33% |
| Researcher | 25 | 27% |
| Student > Bachelor | 6 | 6% |
| Student > Master | 6 | 6% |
| Student > Postgraduate | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 8 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 46% |
| Biochemistry, Genetics and Molecular Biology | 26 | 28% |
| Medicine and Dentistry | 5 | 5% |
| Chemistry | 2 | 2% |
| Physics and Astronomy | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 12 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2014.
All research outputs
#6,360,017
of 24,217,893 outputs
Outputs from Histochemistry and Cell Biology
#180
of 926 outputs
Outputs of similar age
#20,488
of 68,200 outputs
Outputs of similar age from Histochemistry and Cell Biology
#3
of 7 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 926 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,200 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.