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Attention Score in Context
| Title |
Neuroligin-associated microRNA-932 targets actin and regulates memory in the honeybee
|
|---|---|
| Published in |
Nature Communications, November 2014
|
| DOI | 10.1038/ncomms6529 |
| Pubmed ID | |
| Authors |
Alexandre S. Cristino, Angel R. Barchuk, Flavia C. P. Freitas, Ramesh K. Narayanan, Stephanie D. Biergans, Zhengyang Zhao, Zila L. P. Simoes, Judith Reinhard, Charles Claudianos |
| Abstract |
Increasing evidence suggests small non-coding RNAs (ncRNAs) such as microRNAs (miRNAs) control levels of mRNA expression during experience-related remodelling of the brain. Here we use an associative olfactory learning paradigm in the honeybee Apis mellifera to examine gene expression changes in the brain during memory formation. Brain transcriptome analysis reveals a general downregulation of protein-coding genes, including asparagine synthetase and actin, and upregulation of ncRNAs. miRNA-mRNA network predictions together with PCR validation suggest miRNAs including miR-210 and miR-932 target the downregulated protein-coding genes. Feeding cholesterol-conjugated antisense RNA to bees results in the inhibition of miR-210 and of miR-932. Loss of miR-932 impairs long-term memory formation, but not memory acquisition. Functional analyses show that miR-932 interacts with Act5C, providing evidence for direct regulation of actin expression by an miRNA. An activity-dependent increase in miR-932 expression may therefore control actin-related plasticity mechanisms and affect memory formation in the brain. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 77 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 26% |
| Researcher | 18 | 23% |
| Student > Bachelor | 15 | 19% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 2 | 3% |
| Other | 5 | 6% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 41% |
| Biochemistry, Genetics and Molecular Biology | 22 | 28% |
| Neuroscience | 7 | 9% |
| Medicine and Dentistry | 2 | 3% |
| Psychology | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 10 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#1,117,838
of 22,771,140 outputs
Outputs from Nature Communications
#17,007
of 46,906 outputs
Outputs of similar age
#16,190
of 362,064 outputs
Outputs of similar age from Nature Communications
#210
of 693 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,064 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 693 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.