| Title |
RETRACTED ARTICLE: Interleukin-33 promotes helper T cell type-2/17 inflammation in children with allergic rhinitis
|
|---|---|
| Published in |
European Archives of Oto-Rhino-Laryngology, November 2017
|
| DOI | 10.1007/s00405-017-4807-1 |
| Pubmed ID | |
| Authors |
Yuanming Wang, Chuling Li, Xianglin Luo, Deyu Xu, Yaxiong Xu, Guanquan Li, Fang Liao, Shujuan Tan |
| Abstract |
Interleukin-33 is a recently described cytokine which involved in helper T cell type-2 (Th2) mediated diseases. However, its regulatory effect in the pathogenesis of children allergic rhinitis (AR) needs to be further characterized. This study aims to evaluate the expression and role of IL-33 in children with AR. Forty children with AR and twenty normal controls were included. IL-33 and Th cytokine production in serum and nasal lavage was examined by immunosorbent assay (ELISA), respectively. Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-33. The IL-33 protein levels in both serum and nasal lavage were significantly enhanced in AR compared with normal controls, especially in children with asthma. The IL-33 protein expression was correlated to severity of disease. In vitro study showed that IL-33 promotes Th2/17 cytokine expression and thus amplified Th2/17 inflammation. Our results demonstrate that IL-33 expression in AR aggravated and amplified Th2/17 inflammation, and provide a possible explanation for IL-33's regulatory role in the pathogenesis of AR. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 25% |
| Student > Postgraduate | 1 | 13% |
| Student > Bachelor | 1 | 13% |
| Other | 1 | 13% |
| Student > Master | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 38% |
| Immunology and Microbiology | 1 | 13% |
| Linguistics | 1 | 13% |
| Unknown | 3 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2017.
All research outputs
#18,576,855
of 23,008,860 outputs
Outputs from European Archives of Oto-Rhino-Laryngology
#1,667
of 3,113 outputs
Outputs of similar age
#320,074
of 431,651 outputs
Outputs of similar age from European Archives of Oto-Rhino-Laryngology
#22
of 44 outputs
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