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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Limited niche availability suppresses murine intrathymic dendritic-cell development from noncommitted progenitors
|
|---|---|
| Published in |
Blood, November 2014
|
| DOI | 10.1182/blood-2014-07-592667 |
| Pubmed ID | |
| Authors |
Marcin Łyszkiewicz, Natalia Ziętara, Lisa Föhse, Jacek Puchałka, Jana Diestelhorst, Katrin Witzlau, Immo Prinz, Axel Schambach, Andreas Krueger |
| Abstract |
The origins of dendritic cells (DCs) and other myeloid cells in the thymus have remained controversial. Here, we assessed developmental relationships between thymic (t)DCs and thymocytes employing retrovirus-based cellular barcoding, reporter mice as well as intrathymic transfers coupled with DC depletion. We demonstrated that a subset of early T lineage progenitors expressed the bona-fide marker for DC progenitors, CX3CR1. However, intrathymic transfers into non-manipulated mice as well as retroviral barcoding indicated that tDCs and thymocytes were largely of distinct developmental origin. In contrast, intrathymic transfers after in vivo depletion of DC resulted in intrathymic development of non-T lineage cells. In conclusion, our data support a model in which adoption of T lineage fate by non-committed progenitors at steady state is enforced by signals from the thymic microenvironment unless niches promoting alternative lineage fates become available. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 26% |
| Student > Master | 7 | 21% |
| Student > Doctoral Student | 3 | 9% |
| Student > Bachelor | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 7 | 21% |
| Unknown | 2 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 10 | 29% |
| Agricultural and Biological Sciences | 7 | 21% |
| Biochemistry, Genetics and Molecular Biology | 6 | 18% |
| Medicine and Dentistry | 3 | 9% |
| Unspecified | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 7 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2015.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Blood
#27,622
of 33,238 outputs
Outputs of similar age
#227,084
of 369,982 outputs
Outputs of similar age from Blood
#407
of 548 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 33,238 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,982 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 548 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.