Title |
Obesity and the reproductive system disorders: epigenetics as a potential bridge
|
---|---|
Published in |
Human Reproduction Update, November 2014
|
DOI | 10.1093/humupd/dmu060 |
Pubmed ID | |
Authors |
Ana B. Crujeiras, Felipe F. Casanueva |
Abstract |
Obesity and overweight are significantly involved in several reproductive pathologies contributing to infertility in men and women. In addition, several cancers of the reproductive system, such as endometrial, ovarian, breast, testicular and prostate cancers, are strongly influenced by obesity. However, the molecular mechanisms involved in the association between obesity and reproductive disorders remain unclear. Our proposal is to review the current scientific evidence regarding the effect of obesity-related factors as the core of the collective mechanisms directly and indirectly involved in the relationship between obesity and reproductive disorders, with a special and original focus on the effect of the obesity state microenvironment on the epigenetic profile as a reversible mechanistic link between obesity and the reproductive disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 152 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 31 | 20% |
Student > Bachelor | 25 | 16% |
Student > Ph. D. Student | 24 | 16% |
Researcher | 13 | 8% |
Other | 8 | 5% |
Other | 23 | 15% |
Unknown | 30 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 43 | 28% |
Agricultural and Biological Sciences | 24 | 16% |
Biochemistry, Genetics and Molecular Biology | 17 | 11% |
Nursing and Health Professions | 6 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Other | 22 | 14% |
Unknown | 37 | 24% |