| Title |
Myocyte differentiation and body wall muscle regeneration in the planarian Girardia tigrina
|
|---|---|
| Published in |
Development Genes and Evolution, November 1997
|
| DOI | 10.1007/s004270050118 |
| Pubmed ID | |
| Authors |
F. Cebrià, Marcelo Vispo, P. Newmark, David Bueno, Rafael Romero |
| Abstract |
Freshwater planarians (Platyhelminthes, Turbellaria) show a great degree of morphological plasticity, making them a useful model for studying cell differentiation and pattern restoration processes during regeneration. Using confocal microscopy and a monoclonal antibody specific for muscle cells (TMUS-13), we have monitored the restoration of the body wall musculature during head regeneration in whole-mount organisms. Our results show that until the 4th day of regeneration the blastema is occupied by very disorganized muscle fibers, that from this moment become progressively organized restoring the original muscle pattern. In addition to recognizing mature muscle cells, TMUS-13 also recognizes differentiating myocytes, allowing us to trace the origin of newly formed muscle cells. We report that myocytes are detected in the postblastema region as early as day 1 of regeneration. This is the first demonstration that, in addition to serving as a proliferative zone as previously described, overt differentiation begins in the postblastema, at least for muscle cells. We also show that the TMUS13 antigen is the myosin heavy-chain gene from planarians. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Peru | 1 | 1% |
| Belgium | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 62 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 25% |
| Student > Bachelor | 12 | 18% |
| Researcher | 8 | 12% |
| Student > Doctoral Student | 5 | 7% |
| Student > Postgraduate | 5 | 7% |
| Other | 12 | 18% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 51% |
| Biochemistry, Genetics and Molecular Biology | 16 | 24% |
| Earth and Planetary Sciences | 3 | 4% |
| Engineering | 2 | 3% |
| Physics and Astronomy | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 8 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2017.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Development Genes and Evolution
#441
of 509 outputs
Outputs of similar age
#28,269
of 29,632 outputs
Outputs of similar age from Development Genes and Evolution
#4
of 4 outputs
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