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Peptidyl‐prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease

Overview of attention for article published in Clinical & Experimental Pharmacology & Physiology, January 2015
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Title
Peptidyl‐prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
Published in
Clinical & Experimental Pharmacology & Physiology, January 2015
DOI 10.1111/1440-1681.12335
Pubmed ID
Authors

Muhamad A Rostam, Terrence J Piva, Hossein B Rezaei, Danielle Kamato, Peter J Little, Wenhua Zheng, Narin Osman

Abstract

Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are three different classes of PPIases and increasing interest in the development of specific PPIase inhibitors. Cyclosporin A, FK506, rapamycin and juglone are known PPIase inhibitors. In this article, we review recent advances in elucidating the role and regulation of the PPIase family in vascular disease. We will focus on Pin1, an important member of the PPIase family that plays a role in cell cycle progression, gene expression, as well as cell signalling and cell proliferation. Pin1 may be involved in atherosclerosis. The unique role of Pin1 as a molecular switch that impacts on multiple downstream pathways necessitates the evaluation of a highly specific Pin1 inhibitor to aid in a potential therapeutic drug discovery. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 17%
Student > Bachelor 10 17%
Student > Master 9 15%
Professor 5 8%
Researcher 5 8%
Other 10 17%
Unknown 10 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 29%
Chemistry 6 10%
Medicine and Dentistry 5 8%
Agricultural and Biological Sciences 5 8%
Immunology and Microbiology 3 5%
Other 11 19%
Unknown 12 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2014.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Clinical & Experimental Pharmacology & Physiology
#1,215
of 1,426 outputs
Outputs of similar age
#307,290
of 359,790 outputs
Outputs of similar age from Clinical & Experimental Pharmacology & Physiology
#16
of 22 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,426 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,790 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.