| Title |
Neuroprotective Effects of Trans-Caryophyllene Against Kainic Acid Induced Seizure Activity and Oxidative Stress in Mice
|
|---|---|
| Published in |
Neurochemical Research, November 2014
|
| DOI | 10.1007/s11064-014-1474-0 |
| Pubmed ID | |
| Authors |
Hao Liu, Zhi Song, Daguang Liao, Tianyi Zhang, Feng Liu, Kai Zhuang, Kui Luo, Liang Yang |
| Abstract |
Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation. We found that TC pretreatment significantly decreased seizure activity score compared to kainic acid treated group. Importantly, TC pretreatment leads to lowering the mortality in kainic acid treated mice. In addition, TC was found to significantly inhibit KA-induced generation of malondialdehyde. TC pretreatment also preserved the activity of GPx, SOD, and CAT. Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β. These data suggest that TC has a potential protective effect on chemical induced seizure and brain damage. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 22% |
| Student > Bachelor | 5 | 14% |
| Student > Doctoral Student | 4 | 11% |
| Professor > Associate Professor | 4 | 11% |
| Student > Ph. D. Student | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 10 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 14% |
| Medicine and Dentistry | 4 | 11% |
| Chemistry | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 11 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2021.
All research outputs
#7,204,207
of 22,771,140 outputs
Outputs from Neurochemical Research
#564
of 2,091 outputs
Outputs of similar age
#102,630
of 361,726 outputs
Outputs of similar age from Neurochemical Research
#6
of 29 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,091 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.