| Title |
Supplemental Carvacrol Can Reduce the Severity of Inflammation by Influencing the Production of Mediators of Inflammation
|
|---|---|
| Published in |
Inflammation, November 2014
|
| DOI | 10.1007/s10753-014-0066-0 |
| Pubmed ID | |
| Authors |
Mehmet Kara, Sema Uslu, Fatih Demirci, Halide Edip Temel, Canan Baydemir |
| Abstract |
Carvacrol (CVC) is a monoterpenic phenol, which is present in the essential oil of various plants. It has been widely used both as antibacterial feed additive and food preservative. Therefore, our objective was to evaluate the prophylactic effects of carvacrol on inflammatory mediators of sepsis. Serum tumor necrosis factor alpha and interleukin 6 levels as proinflammatory markers were evaluated using an enzyme-linked immunosorbent assay technique. Malondialdehyde (MDA) was determined in the sample by using thiobarbituric acid test. Nitric oxide (NO) levels and arginase activity and also all measurements were evaluated after 24 h from lipopolysaccharide (LPS) injections done (1 mg/kg i.p.). All carvacrol doses (20, 40, and 80 mg/kg) were given by intra gastric gavage during six days before LPS injection (7th day). Proinflammatory cytokines, MDA, NO levels, and arginase activity were decreased by carvacrol according to the carvacrol doses. These results indicate that carvacrol may have a potent anti-inflammatory and antioxidant effects in a dose-dependent manner. Subchronic use of CVC can be assisted to pre-treat of sepsis as a prophylactic. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 8 | 24% |
| Student > Master | 4 | 12% |
| Professor > Associate Professor | 4 | 12% |
| Student > Ph. D. Student | 4 | 12% |
| Other | 3 | 9% |
| Other | 5 | 15% |
| Unknown | 6 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 24% |
| Biochemistry, Genetics and Molecular Biology | 7 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 12% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Other | 5 | 15% |
| Unknown | 7 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#20,243,777
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Outputs from Inflammation
#708
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Outputs of similar age
#302,739
of 361,557 outputs
Outputs of similar age from Inflammation
#17
of 29 outputs
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