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Long noncoding RNA LINC00961 inhibits cell invasion and metastasis in human non-small cell lung cancer

Overview of attention for article published in Biomedicine & Pharmacotherapy, December 2017
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
Long noncoding RNA LINC00961 inhibits cell invasion and metastasis in human non-small cell lung cancer
Published in
Biomedicine & Pharmacotherapy, December 2017
DOI 10.1016/j.biopha.2017.11.062
Pubmed ID
Authors

Bin Jiang, Jing Liu, Yu-hong Zhang, Dong Shen, Shaoping Liu, Feng Lin, Jun Su, Qing-feng Lin, Shuai Yan, Yong Li, Wei-dong Mao, Zhi-li Liu

Abstract

Long noncoding RNAs (LncRNAs) expression has been found to be misregulated in multiple human cancers, and a growing number of studies have revealed that lncRNAs can function as important oncogenes or tumor suppressors. In this study, we identified a lncRNA-LINC00961, which was significantly down-regulated in human non-small cell lung cancer tissues. Decreased LINC00961 was associated with NSCLC patients advanced clinical stage, lymph node metastasis, and shorter survival time. Further experiments demonstrated that LSD1 could directly bind to LINC00961 promoter regions and epigenetically repress its transcription in NSCLC cells. Moreover, MTT assays showed that LINC00961 had no influence on NSCLC cell proliferation. Ectopic overexpression of LINC00961 inhibits NSCLC cell migration, invasion in vitro and metastasis in vivo. Finally, qRT-PCR and western blot assays revealed that LINC00961 could act as a tumor suppressor partially via affecting β-catenin expression. Collectively, decreased LINC00961 might play a key role in NSCLC progression, and may serve as a novel prognostic marker in human NSCLC.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 19%
Researcher 3 19%
Student > Bachelor 2 13%
Student > Ph. D. Student 1 6%
Student > Postgraduate 1 6%
Other 0 0%
Unknown 6 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 38%
Agricultural and Biological Sciences 2 13%
Immunology and Microbiology 1 6%
Unknown 7 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2018.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Biomedicine & Pharmacotherapy
#3,690
of 6,545 outputs
Outputs of similar age
#320,049
of 443,583 outputs
Outputs of similar age from Biomedicine & Pharmacotherapy
#90
of 216 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,545 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,583 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 216 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.