| Title |
Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers
|
|---|---|
| Published in |
Pharmaceutical Research, July 2017
|
| DOI | 10.1007/s11095-017-2229-9 |
| Pubmed ID | |
| Authors |
D. S. Collins, L. C. Kourtis, N. R. Thyagarajapuram, R. Sirkar, S. Kapur, M. W. Harrison, D. J. Bryan, G. B. Jones, J. M. Wright |
| Abstract |
The subcutaneous route offers myriad benefits for the administration of biotherapeutics in both acute and chronic diseases, including convenience, cost effectiveness and the potential for automation through closed-loop systems. Recent advances in parenteral administration devices and the use of additives which enhance drug dispersion have generated substantial additional interest in IV to SQ switching studies. Designing pre-clinical and clinical studies using SQ mediated delivery however requires deep understanding of complex inter-related physiologies and transport pathways governing the interstitial matrix, vascular system and lymphatic channels. This expert review will highlight key structural features which contribute to transport and biodistribution in the subcutaneous space and also assess the impact of drug formulations. Based on the rapidly growing interest in the SQ delivery route, a number of potential areas for future development are highlighted, which are likely to allow continued evolution and innovation in this important area. |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 100 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 15% |
| Other | 15 | 15% |
| Student > Ph. D. Student | 14 | 14% |
| Student > Master | 12 | 12% |
| Student > Bachelor | 7 | 7% |
| Other | 7 | 7% |
| Unknown | 30 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 18% |
| Engineering | 12 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Chemistry | 6 | 6% |
| Medicine and Dentistry | 6 | 6% |
| Other | 17 | 17% |
| Unknown | 33 | 33% |