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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in Parkinson's disease
|
|---|---|
| Published in |
Human Brain Mapping, November 2014
|
| DOI | 10.1002/hbm.22701 |
| Pubmed ID | |
| Authors |
Peter T. Bell, Moran Gilat, Claire O'Callaghan, David A. Copland, Michael J. Frank, Simon J.G. Lewis, James M. Shine |
| Abstract |
The pathological hallmark of Parkinson's disease is the degeneration of dopaminergic nigrostriatal neurons, leading to depletion of striatal dopamine. Recent neuroanatomical work has identified pathways for communication across striatal subdivisions, suggesting that the striatum provides a platform for integration of information across parallel corticostriatal circuits. The aim of this study was to investigate whether dopaminergic dysfunction in Parkinson's disease was associated with impairments in functional connectivity across striatal subdivisions, which could potentially reflect reduced integration across corticostriatal circuits. Utilizing resting-state functional magnetic resonance imaging (fMRI), we analyzed functional connectivity in 39 patients with Parkinson's disease, both "on" and "off" their regular dopaminergic medications, along with 40 age-matched healthy controls. Our results demonstrate widespread impairments in connectivity across subdivisions of the striatum in patients with Parkinson's disease in the "off" state. The administration of dopaminergic medication significantly improved connectivity across striatal subdivisions in Parkinson's disease, implicating dopaminergic deficits in the pathogenesis of impaired striatal interconnectivity. In addition, impaired striatal interconnectivity in the Parkinson's disease "off" state was associated with pathological decoupling of the striatum from the thalamic and sensorimotor (SM) networks. Specifically, we found that although the strength of striatal interconnectivity was positively correlated with both (i) the strength of internal thalamic connectivity, and (ii) the strength of internal SM connectivity, in both healthy controls and the Parkinson's disease "on" state, these relationships were absent in Parkinson's disease when in the "off" state. Taken together our findings emphasize the central role of dopamine in integrated striatal function and the pathological consequences of striatal dopamine denervation in Parkinson's disease. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 121 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 20% |
| Researcher | 22 | 17% |
| Student > Master | 18 | 14% |
| Student > Bachelor | 10 | 8% |
| Student > Doctoral Student | 7 | 6% |
| Other | 18 | 14% |
| Unknown | 26 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 24 | 19% |
| Medicine and Dentistry | 22 | 17% |
| Psychology | 20 | 16% |
| Agricultural and Biological Sciences | 7 | 6% |
| Engineering | 7 | 6% |
| Other | 12 | 10% |
| Unknown | 34 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2014.
All research outputs
#16,699,002
of 24,558,777 outputs
Outputs from Human Brain Mapping
#3,209
of 4,311 outputs
Outputs of similar age
#225,322
of 372,191 outputs
Outputs of similar age from Human Brain Mapping
#63
of 75 outputs
Altmetric has tracked 24,558,777 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,311 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 372,191 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.