| Title |
Bacteriophages targeting intestinal epithelial cells: a potential novel form of immunotherapy
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2017
|
| DOI | 10.1007/s00018-017-2715-6 |
| Pubmed ID | |
| Authors |
Andrzej Górski, Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Jan Borysowski |
| Abstract |
In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that-in addition to their established antibacterial activity-they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 20% |
| Switzerland | 1 | 7% |
| Germany | 1 | 7% |
| Japan | 1 | 7% |
| Spain | 1 | 7% |
| France | 1 | 7% |
| Unknown | 7 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 8 | 53% |
| Members of the public | 6 | 40% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 19% |
| Student > Bachelor | 9 | 13% |
| Student > Doctoral Student | 7 | 10% |
| Student > Master | 7 | 10% |
| Researcher | 6 | 9% |
| Other | 10 | 15% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 18% |
| Agricultural and Biological Sciences | 10 | 15% |
| Immunology and Microbiology | 9 | 13% |
| Medicine and Dentistry | 9 | 13% |
| Engineering | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 18 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2018.
All research outputs
#4,590,732
of 24,953,268 outputs
Outputs from Cellular and Molecular Life Sciences
#950
of 5,667 outputs
Outputs of similar age
#90,454
of 449,778 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#15
of 57 outputs
Altmetric has tracked 24,953,268 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,667 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,778 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.