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Genetics of familial melanoma: 20 years after CDKN2A

Overview of attention for article published in Pigment Cell & Melanoma Research, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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2 X users
wikipedia
1 Wikipedia page
googleplus
1 Google+ user

Citations

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122 Dimensions

Readers on

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152 Mendeley
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Title
Genetics of familial melanoma: 20 years after CDKN2A
Published in
Pigment Cell & Melanoma Research, January 2015
DOI 10.1111/pcmr.12333
Pubmed ID
Authors

Lauren G. Aoude, Karin A. W. Wadt, Antonia L. Pritchard, Nicholas K. Hayward

Abstract

Twenty years ago the first familial melanoma susceptibility gene, CDKN2A, was identified. Two years later, another high penetrance gene, CDK4, was found to be responsible for melanoma development in some families. Progress in identifying new familial melanoma genes was subsequently slow; however, with the advent of next generation sequencing, a small number of new high penetrance genes have recently been uncovered. This approach has identified the lineage specific oncogene MITF as a susceptibility gene both in melanoma families and the general population, as well as the discovery of telomere maintenance as a key pathway underlying melanoma predisposition. Given these rapid recent advances, this approach seems likely to continue to pay dividends. Here we review the currently known familial melanoma genes, providing evidence that most additionally confer risk to other cancers, indicating that they are likely general tumour suppressor genes or oncogenes, which has significant implications for surveillance and screening. This article is protected by copyright. All rights reserved.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 152 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 20%
Student > Ph. D. Student 28 18%
Student > Bachelor 14 9%
Student > Master 13 9%
Student > Doctoral Student 12 8%
Other 25 16%
Unknown 29 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 37 24%
Medicine and Dentistry 35 23%
Agricultural and Biological Sciences 32 21%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Computer Science 2 1%
Other 8 5%
Unknown 34 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2016.
All research outputs
#6,455,731
of 24,484,013 outputs
Outputs from Pigment Cell & Melanoma Research
#190
of 932 outputs
Outputs of similar age
#82,134
of 362,047 outputs
Outputs of similar age from Pigment Cell & Melanoma Research
#7
of 28 outputs
Altmetric has tracked 24,484,013 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 932 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,047 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.