| Title |
The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of acne vulgaris
|
|---|---|
| Published in |
Archives of Dermatological Research, November 2014
|
| DOI | 10.1007/s00403-014-1519-x |
| Pubmed ID | |
| Authors |
S. Younis, Q. Javed |
| Abstract |
Acne vulgaris is a skin disorder with a complex pathogenesis. Better treatment strategies require comprehensive knowledge of molecular factors contributing to the acne pathophysiology. Recent studies are focused on investigating the influence of inflammatory cytokines on the disease. This case-control study investigated the association of IL-6-572 G/C and IL-1A-889 C/T gene polymorphisms with acne in a Pakistani population. Pakistani subjects (380 healthy controls and 430 acne patients) were enrolled in this study. Polymorphism in the promoter region of IL-6-572 and IL-1A-889 was determined by polymerase chain reaction and restriction fragment length polymorphism. The IL-6-572 and IL-1A-889 variant genotypes were significantly associated with the acne pathogenesis. The IL-6-572C and the IL-1A-889T alleles were significantly high in the patient vs. control group (p < 0.0001 for both loci). The IL-6-572 G/C and IL-1A-889 C/T variant allele haplotypes showed significantly high prevalence in patients with acne; G-T (P = 0.0014), C-C (P < 0.0001), and C-T (P < 0.0001). This is the first report on the association between the IL-6-572 G/C polymorphism and acne among any population. The IL-1A-889 C/T polymorphism is also significantly linked with acne in the study population; the -889 C/T association with acne has been reported in one ethnic group previously. Our findings suggest that the IL-6-572C and IL-1A-889T alleles may contribute to the pathogenesis of acne in a Pakistani population. Further studies are required to verify these findings in other populations. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 4% |
| Unknown | 27 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 4 | 14% |
| Student > Postgraduate | 4 | 14% |
| Researcher | 3 | 11% |
| Student > Master | 3 | 11% |
| Unspecified | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 9 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 36% |
| Agricultural and Biological Sciences | 3 | 11% |
| Unspecified | 2 | 7% |
| Immunology and Microbiology | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2014.
All research outputs
#14,791,252
of 22,772,779 outputs
Outputs from Archives of Dermatological Research
#927
of 1,324 outputs
Outputs of similar age
#203,468
of 361,775 outputs
Outputs of similar age from Archives of Dermatological Research
#9
of 20 outputs
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So far Altmetric has tracked 1,324 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
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