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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1
|
|---|---|
| Published in |
Science, November 2014
|
| DOI | 10.1126/science.1258973 |
| Pubmed ID | |
| Authors |
Renjing Wang, Nicole S Persky, Barney Yoo, Ouathek Ouerfelli, Agata Smogorzewska, Stephen J Elledge, Nikola P Pavletich |
| Abstract |
DNA interstrand cross-links (ICLs) are highly toxic lesions associated with cancer and degenerative diseases. ICLs can be repaired by the Fanconi anemia (FA) pathway and through FA-independent processes involving the FAN1 nuclease. In this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA successively at every third nucleotide. In vitro, this exonuclease mechanism allows FAN1 to excise an ICL from one strand through flanking incisions. DNA access requires a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap, suggesting that FAN1 action is coupled to DNA synthesis or recombination. FAN1's mechanism of ICL excision is well suited for processing other localized DNA adducts as well. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Bulgaria | 1 | <1% |
| Unknown | 129 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 25% |
| Researcher | 25 | 19% |
| Student > Master | 10 | 8% |
| Student > Postgraduate | 9 | 7% |
| Professor | 8 | 6% |
| Other | 27 | 20% |
| Unknown | 20 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 33% |
| Agricultural and Biological Sciences | 39 | 30% |
| Chemistry | 11 | 8% |
| Medicine and Dentistry | 10 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 8 | 6% |
| Unknown | 19 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2015.
All research outputs
#6,782,080
of 22,772,779 outputs
Outputs from Science
#46,541
of 77,908 outputs
Outputs of similar age
#94,753
of 361,884 outputs
Outputs of similar age from Science
#500
of 823 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 77,908 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 823 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.