| Title |
International registry on the use of the CytoSorb® adsorber in ICU patients
|
|---|---|
| Published in |
Medizinische Klinik - Intensivmedizin und Notfallmedizin, September 2017
|
| DOI | 10.1007/s00063-017-0342-5 |
| Pubmed ID | |
| Authors |
S. Friesecke, K. Träger, G. A. Schittek, Z. Molnar, F. Bach, K. Kogelmann, R. Bogdanski, A. Weyland, A. Nierhaus, F. Nestler, D. Olboeter, D. Tomescu, D. Jacob, H. Haake, E. Grigoryev, M. Nitsch, A. Baumann, M. Quintel, M. Schott, J. T. Kielstein, A. Meier-Hellmann, F. Born, U. Schumacher, M. Singer, J. Kellum, F. M. Brunkhorst |
| Abstract |
The aim of this clinical registry is to record the use of CytoSorb® adsorber device in critically ill patients under real-life conditions. The registry records all relevant information in the course of product use, e. g., diagnosis, comorbidities, course of the condition, treatment, concomitant medication, clinical laboratory parameters, and outcome (ClinicalTrials.gov Identifier: NCT02312024). Primary endpoint is in-hospital mortality as compared to the mortality predicted by the APACHE II and SAPS II score, respectively. As of January 30, 2017, 130 centers from 22 countries were participating. Data available from the start of the registry on May 18, 2015 to November 24, 2016 (122 centers; 22 countries) were analyzed, of whom 20 centers from four countries provided data for a total of 198 patients (mean age 60.3 ± 15.1 years, 135 men [68.2%]). In all, 192 (97.0%) had 1 to 5 Cytosorb® adsorber applications. Sepsis was the most common indication for CytoSorb® treatment (135 patients). Mean APACHE II score in this group was 33.1 ± 8.4 [range 15-52] with a predicted risk of death of 78%, whereas the observed mortality was 65%. There were no significant decreases in the SOFA scores after treatment (17.2 ± 4.8 [3-24]). However interleukin-6 levels were markedly reduced after treatment (median 5000 pg/ml before and 289 pg/ml after treatment, respectively). This third interim report demonstrates the feasibility of the registry with excellent data quality and completeness from 20 study centers. The results must be interpreted with caution, since the numbers are still small; however the disease severity is remarkably high and suggests that adsorber treatment might be used as an ultimate treatment in life-threatening situations. There were no device-associated side effects. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 25% |
| United Kingdom | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Members of the public | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 15% |
| Other | 5 | 9% |
| Student > Ph. D. Student | 5 | 9% |
| Professor | 4 | 7% |
| Student > Master | 4 | 7% |
| Other | 12 | 22% |
| Unknown | 17 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 44% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Nursing and Health Professions | 2 | 4% |
| Engineering | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 21 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2019.
All research outputs
#13,338,481
of 23,008,860 outputs
Outputs from Medizinische Klinik - Intensivmedizin und Notfallmedizin
#121
of 540 outputs
Outputs of similar age
#154,791
of 315,685 outputs
Outputs of similar age from Medizinische Klinik - Intensivmedizin und Notfallmedizin
#3
of 21 outputs
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So far Altmetric has tracked 540 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 77% of its peers.
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