| Title |
Autonomic and Adrenocortical Interactions Predict Mental Health in Late Adolescence: The TRAILS Study
|
|---|---|
| Published in |
Research on Child and Adolescent Psychopathology, November 2014
|
| DOI | 10.1007/s10802-014-9958-6 |
| Pubmed ID | |
| Authors |
Esther Nederhof, Kristine Marceau, Elizabeth A. Shirtcliff, Paul D. Hastings, Albertine J. Oldehinkel |
| Abstract |
The present study is informed by the theory of allostatic load to examine how multiple stress responsive biomarkers are related to mental health outcomes. Data are from the TRAILS study, a large prospective population study of 715 Dutch adolescents (50.9 % girls), assessed at 16.3 and 19.1 years. Reactivity measures of the hypothalamic pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) biomarkers (heart rate, HR; respiratory sinus arrhythmia, RSA; and pre-ejection period, PEP) to a social stress task were used to predict concurrent and longitudinal changes in internalizing and externalizing symptoms. Hierarchical linear modeling revealed relatively few single effects for each biomarker with the exception that high HR reactivity predicted concurrent internalizing problems in boys. More interestingly, interactions were found between HPA-axis reactivity and sympathetic and parasympathetic reactivity. Boys with high HPA reactivity and low RSA reactivity had the largest increases in internalizing problems from 16 to 19 years. Youth with low HPA reactivity along with increased ANS activation characterized by both decreases in RSA and decreases in PEP had the most concurrent externalizing problems, consistent with broad theories of hypo-arousal. Youth with high HPA reactivity along with increases in RSA but decreases in PEP also had elevated concurrent externalizing problems, which increased over time, especially within boys. This profile illustrates the utility of examining the parasympathetic and sympathetic components of the ANS which can act in opposition to one another to achieve, overall, stress responsivity. The framework of allostasis and allostatic load is supported in that examination of multiple biomarkers working together in concert was of value in understanding mental health problems concurrently and longitudinally. Findings argue against an additive panel of risk and instead illustrate the dynamic interplay of stress physiology systems. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 2 | 33% |
| United States | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Members of the public | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 159 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 27% |
| Student > Master | 22 | 14% |
| Student > Doctoral Student | 15 | 9% |
| Researcher | 12 | 8% |
| Student > Bachelor | 9 | 6% |
| Other | 25 | 16% |
| Unknown | 34 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 65 | 41% |
| Medicine and Dentistry | 15 | 9% |
| Social Sciences | 8 | 5% |
| Neuroscience | 6 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 13 | 8% |
| Unknown | 49 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2014.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Research on Child and Adolescent Psychopathology
#883
of 2,047 outputs
Outputs of similar age
#113,298
of 369,553 outputs
Outputs of similar age from Research on Child and Adolescent Psychopathology
#6
of 20 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,047 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.