| Title |
Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, November 2017
|
| DOI | 10.1007/s10803-017-3406-8 |
| Pubmed ID | |
| Authors |
Andreia Carvalho Pereira, Inês R. Violante, Susana Mouga, Guiomar Oliveira, Miguel Castelo-Branco |
| Abstract |
The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased Glx/tNAA but unchanged glutamate + glutamine (Glx) and unchanged absolute or relative gamma-aminobutyric acid (GABA+) in the ASD group. Importantly, both smaller absolute and relative GABA+ levels were associated with worse communication skills and developmental delay scores assessed by the autism diagnostic interview-revised (ADI-R). We conclude that tNAA is reduced in the mPFC in ASD and that glutamatergic metabolism may be altered due to unbalanced Glx/tNAA. Moreover, GABA+ is related to autistic symptoms assessed by the ADI-R. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 96 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 15% |
| Researcher | 11 | 11% |
| Student > Bachelor | 10 | 10% |
| Student > Ph. D. Student | 10 | 10% |
| Student > Doctoral Student | 7 | 7% |
| Other | 12 | 13% |
| Unknown | 32 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 17% |
| Medicine and Dentistry | 10 | 10% |
| Psychology | 9 | 9% |
| Nursing and Health Professions | 5 | 5% |
| Social Sciences | 5 | 5% |
| Other | 13 | 14% |
| Unknown | 38 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2017.
All research outputs
#21,376,200
of 23,867,274 outputs
Outputs from Journal of Autism and Developmental Disorders
#4,711
of 5,240 outputs
Outputs of similar age
#380,295
of 444,495 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#109
of 124 outputs
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