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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy
|
|---|---|
| Published in |
Biochimica et Biophysica Acta (BBA), November 2014
|
| DOI | 10.1016/j.bbagrm.2014.10.007 |
| Pubmed ID | |
| Authors |
Simone J. Woods, Katherine M. Hannan, Richard B. Pearson, Ross D. Hannan |
| Abstract |
Recent studies have highlighted the fundamental role that key oncogenes such as MYC, RAS and PI3K occupy in driving RNA Polymerase I transcription in the nucleolus. In addition to maintaining essential levels of protein synthesis, hyperactivated ribosome biogenesis and nucleolar function plays a central role in suppressing p53 activation in response to oncogenic stress. Consequently, disruption of ribosome biogenesis by agents such as the small molecule inhibitor of RNA Polymerase I transcription, CX-5461, has shown unexpected, potent, and selective effects in killing tumour cells via disruption of nucleolar function leading to activation of p53, independent of DNA damage. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 25% |
| Thailand | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| United States | 1 | <1% |
| Unknown | 154 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 21% |
| Student > Bachelor | 25 | 16% |
| Researcher | 20 | 13% |
| Student > Master | 20 | 13% |
| Student > Doctoral Student | 8 | 5% |
| Other | 20 | 13% |
| Unknown | 31 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 32% |
| Agricultural and Biological Sciences | 35 | 22% |
| Medicine and Dentistry | 15 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Chemistry | 7 | 4% |
| Other | 7 | 4% |
| Unknown | 35 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2024.
All research outputs
#6,409,980
of 25,373,627 outputs
Outputs from Biochimica et Biophysica Acta (BBA)
#5,209
of 19,218 outputs
Outputs of similar age
#65,299
of 271,249 outputs
Outputs of similar age from Biochimica et Biophysica Acta (BBA)
#50
of 268 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 19,218 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 268 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.