Title |
Structural basis of cell apoptosis and necrosis in TNFR signaling
|
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Published in |
Apoptosis, December 2014
|
DOI | 10.1007/s10495-014-1061-5 |
Pubmed ID | |
Authors |
Jing Huang, Shaoning Yu, Chaoneng Ji, Jixi Li |
Abstract |
The tumor necrosis factor receptors (TNFRs) play essential roles in innate and adaptive immunity. Depending on conditions, TNFR induces multiple cell fates including cell survival, cell apoptosis, and cell programmed necrosis. Here, we review recent progress in structural studies of the TNFR signaling pathway. The structural basis for the high order signal complexes, including the DISC, ripoptosome, necrosome, and RIP3/MLKL complex, may provide novel insights for understanding the biophysical principles of cell signaling cascades. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Student > Master | 10 | 19% |
Student > Doctoral Student | 6 | 11% |
Researcher | 6 | 11% |
Student > Bachelor | 4 | 8% |
Other | 5 | 9% |
Unknown | 12 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 32% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Medicine and Dentistry | 6 | 11% |
Immunology and Microbiology | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 4 | 8% |
Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2015.
All research outputs
#20,245,139
of 22,772,779 outputs
Outputs from Apoptosis
#631
of 803 outputs
Outputs of similar age
#302,546
of 361,258 outputs
Outputs of similar age from Apoptosis
#8
of 17 outputs
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