| Title |
A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis
|
|---|---|
| Published in |
Proceedings: Plant Sciences, December 2009
|
| DOI | 10.1007/s12038-009-0100-9 |
| Pubmed ID | |
| Authors |
Enrique Meléndez-Hevia, Patricia de Paz-Lugo, Athel Cornish-Bowden, María Luz Cárdenas |
| Abstract |
In a previous paper, we pointed out that the capability to synthesize glycine from serine is constrained by the stoichiometry of the glycine hydroxymethyltransferase reaction, which limits the amount of glycine produced to be no more than equimolar with the amount of C 1 units produced. This constraint predicts a shortage of available glycine if there are no adequate compensating processes. Here, we test this prediction by comparing all reported fl uxes for the production and consumption of glycine in a human adult. Detailed assessment of all possible sources of glycine shows that synthesis from serine accounts for more than 85% of the total, and that the amount of glycine available from synthesis, about 3 g/day, together with that available from the diet, in the range 1.5-3.0 g/day, may fall significantly short of the amount needed for all metabolic uses, including collagen synthesis by about 10 g per day for a 70 kg human. This result supports earlier suggestions in the literature that glycine is a semi-essential amino acid and that it should be taken as a nutritional supplement to guarantee a healthy metabolism. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 16% |
| France | 2 | 5% |
| Canada | 2 | 5% |
| Curaçao | 1 | 2% |
| Kuwait | 1 | 2% |
| Iran, Islamic Republic of | 1 | 2% |
| United Kingdom | 1 | 2% |
| Spain | 1 | 2% |
| South Africa | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 24 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 70% |
| Practitioners (doctors, other healthcare professionals) | 7 | 16% |
| Scientists | 6 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Malaysia | 1 | <1% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Unknown | 153 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 20% |
| Student > Ph. D. Student | 21 | 13% |
| Student > Master | 17 | 11% |
| Student > Bachelor | 16 | 10% |
| Student > Postgraduate | 12 | 8% |
| Other | 25 | 16% |
| Unknown | 36 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 20% |
| Biochemistry, Genetics and Molecular Biology | 22 | 14% |
| Medicine and Dentistry | 14 | 9% |
| Chemistry | 7 | 4% |
| Nursing and Health Professions | 6 | 4% |
| Other | 26 | 16% |
| Unknown | 51 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2024.
All research outputs
#605,674
of 25,709,917 outputs
Outputs from Proceedings: Plant Sciences
#4
of 989 outputs
Outputs of similar age
#1,939
of 179,026 outputs
Outputs of similar age from Proceedings: Plant Sciences
#1
of 14 outputs
Altmetric has tracked 25,709,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 989 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.