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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells
|
|---|---|
| Published in |
Scientific Reports, November 2017
|
| DOI | 10.1038/s41598-017-15283-y |
| Pubmed ID | |
| Authors |
Angela Lombardi, Jessica Gambardella, Xue-Liang Du, Daniela Sorriento, Maurizio Mauro, Guido Iaccarino, Bruno Trimarco, Gaetano Santulli |
| Abstract |
Sirolimus (rapamycin) is an immunosuppressive drug used in transplantation. One of its major side effects is the increased risk of diabetes mellitus; however, the exact mechanisms underlying such association have not been elucidated. Here we show that sirolimus impairs glucose-stimulated insulin secretion both in human and murine pancreatic islets and in clonal β cells in a dose- and time-dependent manner. Importantly, we demonstrate that sirolimus markedly depletes calcium (Ca(2+)) content in the endoplasmic reticulum and significantly decreases glucose-stimulated mitochondrial Ca(2+) uptake. Crucially, the reduced mitochondrial Ca(2+) uptake is mirrored by a significant impairment in mitochondrial respiration. Taken together, our findings indicate that sirolimus causes depletion of intracellular Ca(2+) stores and alters mitochondrial fitness, eventually leading to decreased insulin release. Our results provide a novel molecular mechanism underlying the increased incidence of diabetes mellitus in patients treated with this drug. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 17% |
| Researcher | 5 | 14% |
| Student > Master | 4 | 11% |
| Professor > Associate Professor | 3 | 9% |
| Unspecified | 3 | 9% |
| Other | 6 | 17% |
| Unknown | 8 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 17% |
| Agricultural and Biological Sciences | 6 | 17% |
| Medicine and Dentistry | 6 | 17% |
| Unspecified | 3 | 9% |
| Nursing and Health Professions | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 10 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2017.
All research outputs
#15,463,376
of 23,751,351 outputs
Outputs from Scientific Reports
#75,844
of 128,205 outputs
Outputs of similar age
#255,587
of 441,182 outputs
Outputs of similar age from Scientific Reports
#2,226
of 4,068 outputs
Altmetric has tracked 23,751,351 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 128,205 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,182 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,068 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.