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Deficiency of essential dietary n-3 PUFA disrupts the caecal microbiome and metabolome in mice

Overview of attention for article published in British Journal of Nutrition, November 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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2 news outlets
blogs
1 blog
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44 X users

Citations

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39 Dimensions

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93 Mendeley
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Title
Deficiency of essential dietary n-3 PUFA disrupts the caecal microbiome and metabolome in mice
Published in
British Journal of Nutrition, November 2017
DOI 10.1017/s0007114517002999
Pubmed ID
Authors

Ruairi C. Robertson, Clara Seira Oriach, Kiera Murphy, Gerard M. Moloney, John F. Cryan, Timothy G. Dinan, R. P. Ross, Catherine Stanton

Abstract

n-3 PUFA are lipids that play crucial roles in immune-regulation, cardio-protection and neurodevelopment. However, little is known about the role that these essential dietary fats play in modulating caecal microbiota composition and the subsequent production of functional metabolites. To investigate this, female C57BL/6 mice were assigned to one of three diets (control (CON), n-3 supplemented (n3+) or n-3 deficient (n3-)) during gestation, following which their male offspring were continued on the same diets for 12 weeks. Caecal content of mothers and offspring were collected for 16S sequencing and metabolic phenotyping. n3- male offspring displayed significantly less % fat mass than n3+ and CON. n-3 Status also induced a number of changes to gut microbiota composition such that n3- offspring had greater abundance of Tenericutes, Anaeroplasma and Coriobacteriaceae. Metabolomics analysis revealed an increase in caecal metabolites involved in energy metabolism in n3+ including α-ketoglutaric acid, malic acid and fumaric acid. n3- animals displayed significantly reduced acetate, butyrate and total caecal SCFA production. These results demonstrate that dietary n-3 PUFA regulate gut microbiota homoeostasis whereby n-3 deficiency may induce a state of disturbance. Further studies are warranted to examine whether these microbial and metabolic disturbances are causally related to changes in metabolic health outcomes.

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The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 93 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 24%
Researcher 11 12%
Student > Master 9 10%
Student > Doctoral Student 9 10%
Student > Bachelor 7 8%
Other 16 17%
Unknown 19 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 17%
Biochemistry, Genetics and Molecular Biology 14 15%
Medicine and Dentistry 11 12%
Immunology and Microbiology 6 6%
Neuroscience 6 6%
Other 15 16%
Unknown 25 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2023.
All research outputs
#915,436
of 25,397,764 outputs
Outputs from British Journal of Nutrition
#505
of 6,281 outputs
Outputs of similar age
#20,653
of 446,500 outputs
Outputs of similar age from British Journal of Nutrition
#6
of 52 outputs
Altmetric has tracked 25,397,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,281 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.5. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,500 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.