| Title |
Smoking is associated with mosaic loss of chromosome Y
|
|---|---|
| Published in |
Science, December 2014
|
| DOI | 10.1126/science.1262092 |
| Pubmed ID | |
| Authors |
Jan P Dumanski, Chiara Rasi, Mikael Lönn, Hanna Davies, Martin Ingelsson, Vilmantas Giedraitis, Lars Lannfelt, Patrik K E Magnusson, Cecilia M Lindgren, Andrew P Morris, David Cesarini, Magnus Johannesson, Eva Tiensuu Janson, Lars Lind, Nancy L Pedersen, Erik Ingelsson, Lars A Forsberg |
| Abstract |
Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. |
X Demographics
The data shown below were collected from the profiles of 126 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 23 | 18% |
| Saudi Arabia | 9 | 7% |
| Japan | 4 | 3% |
| Sweden | 4 | 3% |
| United Kingdom | 4 | 3% |
| Turkey | 3 | 2% |
| Australia | 3 | 2% |
| Kuwait | 3 | 2% |
| Germany | 3 | 2% |
| Other | 17 | 13% |
| Unknown | 53 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 83 | 66% |
| Scientists | 30 | 24% |
| Practitioners (doctors, other healthcare professionals) | 11 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 3% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Norway | 1 | <1% |
| Japan | 1 | <1% |
| Romania | 1 | <1% |
| Unknown | 199 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 25% |
| Researcher | 44 | 21% |
| Student > Bachelor | 23 | 11% |
| Student > Master | 18 | 9% |
| Other | 11 | 5% |
| Other | 37 | 18% |
| Unknown | 25 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 59 | 28% |
| Agricultural and Biological Sciences | 56 | 27% |
| Medicine and Dentistry | 33 | 16% |
| Computer Science | 6 | 3% |
| Neuroscience | 6 | 3% |
| Other | 22 | 10% |
| Unknown | 29 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 409. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2024.
All research outputs
#74,251
of 25,914,360 outputs
Outputs from Science
#2,635
of 83,410 outputs
Outputs of similar age
#667
of 370,567 outputs
Outputs of similar age from Science
#32
of 854 outputs
Altmetric has tracked 25,914,360 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,410 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,567 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 854 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.