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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity
|
|---|---|
| Published in |
Nature Immunology, November 2017
|
| DOI | 10.1038/s41590-017-0005-y |
| Pubmed ID | |
| Authors |
Jessica J. Chiang, Konstantin M. J. Sparrer, Michiel van Gent, Charlotte Lässig, Teng Huang, Nikolaus Osterrieder, Karl-Peter Hopfner, Michaela U. Gack |
| Abstract |
The sensor RIG-I detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to have a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG-I during infection with a DNA virus are largely unknown. Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1). Infection with HSV-1 induced relocalization of RNA5SP141 from the nucleus to the cytoplasm, and virus-induced shutoff of host protein synthesis downregulated the abundance of RNA5SP141-interacting proteins, which allowed RNA5SP141 to bind RIG-I and induce the expression of type I interferons. Silencing of RNA5SP141 strongly dampened the antiviral response to HSV-1 and the related virus Epstein-Barr virus (EBV), as well as influenza A virus (IAV). Our findings reveal that antiviral immunity can be triggered by host RNAs that are unshielded following depletion of their respective binding proteins by the virus. |
X Demographics
The data shown below were collected from the profiles of 53 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 36% |
| France | 6 | 11% |
| United Kingdom | 4 | 8% |
| Singapore | 1 | 2% |
| Australia | 1 | 2% |
| Sweden | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 20 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 47% |
| Scientists | 24 | 45% |
| Science communicators (journalists, bloggers, editors) | 3 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 175 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 22% |
| Researcher | 30 | 17% |
| Student > Master | 23 | 13% |
| Student > Bachelor | 16 | 9% |
| Student > Doctoral Student | 8 | 5% |
| Other | 28 | 16% |
| Unknown | 31 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 50 | 29% |
| Agricultural and Biological Sciences | 31 | 18% |
| Immunology and Microbiology | 29 | 17% |
| Medicine and Dentistry | 13 | 7% |
| Chemistry | 3 | 2% |
| Other | 12 | 7% |
| Unknown | 37 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2023.
All research outputs
#1,219,026
of 25,321,938 outputs
Outputs from Nature Immunology
#792
of 4,166 outputs
Outputs of similar age
#27,220
of 452,199 outputs
Outputs of similar age from Nature Immunology
#12
of 39 outputs
Altmetric has tracked 25,321,938 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,166 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,199 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.