Title |
TBCRC 008: Early Change in 18F-FDG Uptake on PET Predicts Response to Preoperative Systemic Therapy in Human Epidermal Growth Factor Receptor 2–Negative Primary Operable Breast Cancer
|
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Published in |
Journal of Nuclear Medicine, December 2014
|
DOI | 10.2967/jnumed.114.144741 |
Pubmed ID | |
Authors |
Roisin M Connolly, Jeffrey P Leal, Matthew P Goetz, Zhe Zhang, Xian C Zhou, Lisa K Jacobs, Joyce Mhlanga, Joo H O, John Carpenter, Anna Maria Storniolo, Stanley Watkins, John H Fetting, Robert S Miller, Kostandinos Sideras, Stacie C Jeter, Bridget Walsh, Penny Powers, Jane Zorzi, Judy C Boughey, Nancy E Davidson, Lisa A Carey, Antonio C Wolff, Nagi Khouri, Edward Gabrielson, Richard L Wahl, Vered Stearns |
Abstract |
Epigenetic modifiers, including the histone deacetylase inhibitor vorinostat, may sensitize tumors to chemotherapy and enhance outcomes. We conducted a multicenter randomized phase II neoadjuvant trial of carboplatin and nanoparticle albumin-bound paclitaxel (CP) with vorinostat or placebo in women with stage II/III, HER2-negative breast cancer, in which we also examined whether change in maximum standardized uptake values corrected for lean body mass (SULmax) on FDG-PET predicted pathologic complete response (pCR) in breast and axillary lymph nodes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 81 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 13% |
Student > Bachelor | 11 | 13% |
Other | 9 | 11% |
Student > Master | 8 | 10% |
Student > Ph. D. Student | 7 | 8% |
Other | 17 | 20% |
Unknown | 20 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 43% |
Nursing and Health Professions | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Agricultural and Biological Sciences | 3 | 4% |
Psychology | 2 | 2% |
Other | 8 | 10% |
Unknown | 23 | 28% |