| Title |
Antigiardial activity of Ocimum basilicum essential oil
|
|---|---|
| Published in |
Parasitology Research, March 2007
|
| DOI | 10.1007/s00436-007-0502-2 |
| Pubmed ID | |
| Authors |
Igor de Almeida, Daniela Sales Alviano, Danielle Pereira Vieira, Péricles Barreto Alves, Arie Fitzgerald Blank, Angela Hampshire C. S. Lopes, Celuta Sales Alviano, Maria do Socorro S. Rosa |
| Abstract |
In this study, we investigated the effects of Ocimum basilicum essential oil on Giardia lamblia and on the modulation of the interaction of these parasites by peritoneal mouse macrophage. The essential oil (2 mg/ml) and its purified substances demonstrated antigiardial activity. Linalool (300 microg/ml), however, was able to kill 100% parasites after 1 h of incubation, which demonstrates its high antigiardial potential. Pretreatment of peritoneal mouse macrophages with 2 mg/ml essential oil dilution reduced in 79% the association index between these macrophages and G. lamblia, with a concomitant increase by 153% on nitric oxide production by the G. lamblia-ingested macrophages. The protein profiles and proteolitic activity of these parasite trophozoites, previously treated or not with 2 mg/ml essential oil or with the purified fractions, were also determined. After 1 and 2 h of incubation, proteins of lysates and culture supernatants revealed significant differences in bands patterns when compared to controls. Besides, the proteolitic activity, mainly of cysteine proteases, was clearly inhibited by the essential oil (2 mg/ml) and the purified linalool (300 microg/ml). These results suggest that, with G. lamblia, the essential oil from O. basilicum and its purified compounds, specially linalool, have a potent antimicrobial activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| United States | 1 | 1% |
| Italy | 1 | 1% |
| China | 1 | 1% |
| Unknown | 91 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 20% |
| Student > Master | 14 | 15% |
| Student > Bachelor | 14 | 15% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Postgraduate | 7 | 7% |
| Other | 16 | 17% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 34% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 10% |
| Medicine and Dentistry | 7 | 7% |
| Chemistry | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 19 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2017.
All research outputs
#4,596,403
of 22,772,779 outputs
Outputs from Parasitology Research
#264
of 3,781 outputs
Outputs of similar age
#14,337
of 76,050 outputs
Outputs of similar age from Parasitology Research
#2
of 12 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,781 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.