| Title |
Neuronal density and proportion of interneurons in the associative, sensorimotor and limbic human striatum
|
|---|---|
| Published in |
Brain Structure and Function, November 2017
|
| DOI | 10.1007/s00429-017-1579-8 |
| Pubmed ID | |
| Authors |
A. Lecumberri, A. Lopez-Janeiro, C. Corral-Domenge, Javier Bernacer |
| Abstract |
The striatum (caudate nucleus, putamen and nucleus accumbens) is the main input structure of the basal ganglia. It receives cortical projections from the vast majority of the cortex, as well as from other subcortical structures such as the thalamus and amygdala. Its role in planning, preparation and execution of voluntary movements is known to be fine-tuned by the interaction between projection neurons and interneurons. Since the 1990s, it has been accepted that the proportion of interneurons increases phylogenetically, being about 5% in rodents and 26% in humans. However, these data have not been confirmed with unbiased techniques, such as stereology. In the present report, we have divided the human striatum into functional territories (associative, sensorimotor and limbic) and we have quantified the numerical density of all striatal neurons (using Nissl staining) in each area. Taking into account our past research on the estimation of striatal interneurons, we have calculated the proportion of interneurons in each territory. This value was on average 17.1% for the whole striatum, although interneurons were more abundant in the associative (21.9%) than in the sensorimotor (12.8%) and limbic (11.1%) aspects. Therefore, we demonstrate with unbiased stereology that the overall proportion of striatal interneurons is slightly lower than that reported in previous studies, and that it varies in the functional territories of this structure. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 6 | 19% |
| Researcher | 6 | 19% |
| Student > Master | 4 | 13% |
| Student > Bachelor | 3 | 9% |
| Librarian | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 9 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 28% |
| Medicine and Dentistry | 6 | 19% |
| Agricultural and Biological Sciences | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Computer Science | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 9 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2017.
All research outputs
#16,454,538
of 24,217,893 outputs
Outputs from Brain Structure and Function
#1,015
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Outputs of similar age
#274,489
of 446,191 outputs
Outputs of similar age from Brain Structure and Function
#23
of 55 outputs
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