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Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis.

Overview of attention for article published in Acta Dermato-Venereologica, January 2018
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Title
Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis.
Published in
Acta Dermato-Venereologica, January 2018
DOI 10.2340/00015555-2852
Pubmed ID
Authors

Louise Lönndahl, Mikael Holst, Maria Bradley, Hassan Killasli, Johan Heilborn, Martin A Hall, Elvar Theodorsson, Jadwiga Holmberg, Klas Nordlind

Abstract

Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus, stress and anxiety. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate-severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 14%
Researcher 5 12%
Other 4 9%
Student > Ph. D. Student 4 9%
Student > Postgraduate 3 7%
Other 8 19%
Unknown 13 30%
Readers by discipline Count As %
Medicine and Dentistry 15 35%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Agricultural and Biological Sciences 2 5%
Nursing and Health Professions 2 5%
Neuroscience 2 5%
Other 6 14%
Unknown 14 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
All research outputs
#16,033,957
of 25,806,080 outputs
Outputs from Acta Dermato-Venereologica
#1,120
of 2,121 outputs
Outputs of similar age
#250,637
of 452,369 outputs
Outputs of similar age from Acta Dermato-Venereologica
#45
of 156 outputs
Altmetric has tracked 25,806,080 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,121 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,369 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 156 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.