Title |
Insertion sequence transpositions and point mutations in mgrB causing colistin resistance in a clinical strain of carbapenem-resistant Klebsiella pneumoniae from Vietnam
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Published in |
International Journal of Antimicrobial Agents, November 2017
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DOI | 10.1016/j.ijantimicag.2017.11.012 |
Pubmed ID | |
Authors |
Björn Berglund, Ngoc Thi Bich Hoang, Maria Tärnberg, Ngai Kien Le, Olov Svartström, Dung Thi Khanh Khu, Maud Nilsson, Hai Thanh Le, Jenny Welander, Linus Olson, Mattias Larsson, Lennart E. Nilsson, Håkan Hanberger |
Abstract |
Resistance among Klebsiella pneumoniae to the last resort antibiotics carbapenems and colistin is increasing worldwide. In this study, we used whole-genome sequencing to determine the colistin resistance mechanisms in clinical isolates of carbapenem- and colistin-resistant K. pneumoniae from Vietnam. Alterations in the regulatory gene mgrB, via mutations and insertion sequence transpositions, was found in 30 of 31 isolates, emphasizing the importance of this resistance mechanism in colistin-resistant K. pneumoniae. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Vietnam | 1 | 25% |
Australia | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 24% |
Student > Bachelor | 7 | 13% |
Student > Master | 6 | 11% |
Student > Ph. D. Student | 4 | 7% |
Professor | 2 | 4% |
Other | 4 | 7% |
Unknown | 18 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 14 | 26% |
Medicine and Dentistry | 8 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 6 | 11% |
Unknown | 19 | 35% |