| Title |
Relationship of hepatitis B virus infection to the recurrence of hepatocellular carcinoma after direct acting antivirals
|
|---|---|
| Published in |
Indian Journal of Gastroenterology, May 2017
|
| DOI | 10.1007/s12664-017-0755-3 |
| Pubmed ID | |
| Authors |
Hirohito Shimizu, Keiji Matsui, Shogo Iwabuchi, Tomoaki Fujikawa, Mitsuru Nagata, Kentaro Takatsuka, Hiroyuki Tanemura, Haruhiro Nakazaki, Masayuki Nakano, Tsunamasa Watanabe |
| Abstract |
Recently, two conflicting articles about recurrence of hepatocellular carcinoma (HCC) after direct acting antivirals (DAA) against hepatitis C virus (HCV) were published. We investigated the relationship between DAA and HCC recurrence. Eligible patients were (1) history of HCC and treated curatively with interventions, and (2) interferon-free DAA therapy was initiated after eradication of HCC. We analyzed contributing factor for HCC recurrence. Ten out of 23 participants (43%) encountered recurrence of HCC. Age, sex, diabetes mellitus, fibrosis score, chemistry, and alpha-fetoprotein did not differ between patients with recurrence and patients without recurrence. The patients with recurrence had significantly higher values of antibody to hepatitis B core antigen (anti-HBc) than the patients without recurrence, 6.06±3.75 vs. 0.91±2.43 (p=0.0019). The relative risk of HCC recurrence comparing anti-HBc positive to negative was 5.2 (95% confidence interval 1.40 to 19.32). Odds ratio was 22.0 (95% confidence interval 2.5 to 191.1). We conclude that anti-HBc positivity was a strong contributing factor for HCC recurrence after DAA therapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 4 | 15% |
| Researcher | 3 | 11% |
| Student > Postgraduate | 3 | 11% |
| Student > Master | 2 | 7% |
| Student > Doctoral Student | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 10 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 59% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Unknown | 10 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2017.
All research outputs
#18,577,751
of 23,009,818 outputs
Outputs from Indian Journal of Gastroenterology
#235
of 357 outputs
Outputs of similar age
#241,131
of 316,111 outputs
Outputs of similar age from Indian Journal of Gastroenterology
#4
of 6 outputs
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