| Title |
The epidemiological profile of ASIA syndrome after HPV vaccination: an evaluation based on the Vaccine Adverse Event Reporting Systems
|
|---|---|
| Published in |
Immunologic Research, November 2014
|
| DOI | 10.1007/s12026-014-8567-3 |
| Pubmed ID | |
| Authors |
Paolo Pellegrino, Valentina Perrone, Marco Pozzi, Carla Carnovale, Cristiana Perrotta, Emilio Clementi, Sonia Radice |
| Abstract |
The term "ASIA-Autoimmune/inflammatory Syndrome Induced by Adjuvants" describes an umbrella of clinical conditions sharing similar signs or symptoms, including post-vaccination phenomena. No information is available on the epidemiology of the ASIA syndrome, especially following HPV vaccination. We carried out an analysis of the VAERS database to retrieve all cases of suspected ASIA syndrome according to the Shoenfeld and Agmon-Levin's guideline for the diagnosis. After causality assessment and case validation, 2,207 cases were considered probably or possibly related to vaccination. These represent the largest ASIA cohort ever reported and allowed us to estimate epidemiological and clinical characteristic of this syndrome. The commonest clinical manifestation observed were pyrexia (58 %), myalgia (27 %) and arthralgia or arthritis (19 %), and the estimated reporting rate was of 3.6 cases per 100,000 doses of HPV vaccine distributed (95 % CI 3.4-3.7). This study presents the first systematic estimation of ASIA incidence and expands the knowledge on this pathology. Further analyses are needed to identify genetic and non-genetic risk factors for ASIA syndrome. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 23% |
| Japan | 4 | 13% |
| Australia | 2 | 7% |
| Canada | 1 | 3% |
| Colombia | 1 | 3% |
| Unknown | 15 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 93% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 2% |
| Unknown | 65 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 15% |
| Other | 9 | 14% |
| Student > Doctoral Student | 8 | 12% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 6 | 9% |
| Other | 16 | 24% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 44% |
| Agricultural and Biological Sciences | 6 | 9% |
| Nursing and Health Professions | 5 | 8% |
| Unspecified | 3 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 15 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2018.
All research outputs
#1,405,748
of 25,158,951 outputs
Outputs from Immunologic Research
#43
of 939 outputs
Outputs of similar age
#15,927
of 269,340 outputs
Outputs of similar age from Immunologic Research
#6
of 32 outputs
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