| Title |
The association between maternal blood pressures and offspring size at birth in Southeast Asian women
|
|---|---|
| Published in |
BMC Pregnancy and Childbirth, December 2014
|
| DOI | 10.1186/s12884-014-0403-1 |
| Pubmed ID | |
| Authors |
Wai-Yee Lim, Yung-Seng Lee, Chuen-Seng Tan, Kenneth Kwek, Yap-Seng Chong, Peter D Gluckman, Keith M Godfrey, Seang-Mei Saw, An Pan |
| Abstract |
BackgroundMaternal blood pressures in pregnancy is an important determinant of offspring size at birth. However, the relationship between maternal blood pressures and offspring¿s size at birth is not consistent and may vary between ethnic groups. We examined the relationship between maternal peripheral and central blood pressures and offspring size at birth in an Asian multi-ethnic cohort, and effect modifications by maternal ethnicity and obesity.MethodsWe used data from 713 participants in the Growing Up in Singapore Towards Healthy Outcomes study consisting of pregnant Chinese, Malay and Indian women recruited from two tertiary hospitals between 2009 to 2010. Peripheral systolic and diastolic blood pressures (SBP and DBP), and central SBP and pulse pressure (PP) were measured around 27 weeks of gestation. Biometric parameters at birth were collected from medical records.ResultsAfter adjusting for maternal and fetal covariates, each 1-SD increase (10.0 mmHg) in central SBP was inversely associated with birth weight (¿40.52 g; 95% confidence interval (CI) -70.66 to ¿10.37), birth length (¿0.19 cm; ¿0.36 to ¿0.03), head circumference (¿0.12 cm; ¿0.23 to ¿0.02) and placental weight (¿11.16 g; ¿20.85 to ¿1.47). A one-SD (11.1 mmHg) increase in peripheral SBP was also associated with lower birth weight (¿35.56 g; ¿66.57 to ¿4.54). The inverse relations between other blood pressure measures and offspring size at birth were observed but not statistically significant. Higher peripheral SBP and DBP and central SBP were associated with increased odds of low birth weight (defined as weight <2500 g) and small for gestational age (defined as <10th percentile for gestational age adjusted birth weight). Maternal adiposity modified these associations, with stronger inverse associations in normal weight women. No significant interactions were found with ethnicity.ConclusionsHigher second-trimester peripheral and central systolic pressures were associated with smaller offspring size at birth, particularly in normal weight women. Findings from this study reinforces the clinical relevance of antenatal blood pressure monitoring. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 1 | 2% |
| Unknown | 65 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 15% |
| Student > Ph. D. Student | 9 | 14% |
| Researcher | 7 | 11% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 4 | 6% |
| Other | 12 | 18% |
| Unknown | 17 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 29% |
| Nursing and Health Professions | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Psychology | 4 | 6% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 10 | 15% |
| Unknown | 20 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2014.
All research outputs
#14,663,954
of 22,774,233 outputs
Outputs from BMC Pregnancy and Childbirth
#2,813
of 4,183 outputs
Outputs of similar age
#200,539
of 361,266 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#41
of 62 outputs
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