| Title |
Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort
|
|---|---|
| Published in |
Diabetologia, November 2017
|
| DOI | 10.1007/s00125-017-4503-0 |
| Pubmed ID | |
| Authors |
Roy Taylor, Wilma S. Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Naveed Sattar, Paul Welsh, Carl Peters, Sviatlana Zhyzhneuskaya, Kieren G. Hollingsworth, Ahmad Al-Mrabeh, Angela M. Rodrigues, Lucia Rehackova, Ashley J. Adamson, Falko F. Sniehotta, John C. Mathers, Hazel M. Ross, Yvonne McIlvenna, Sharon Kean, Ian Ford, Alex McConnachie, Michael E. J. Lean |
| Abstract |
Substantial weight loss in type 2 diabetes can achieve a return to non-diabetic biochemical status, without the need for medication. The Diabetes Remission Clinical Trial (DiRECT), a cluster-randomised controlled trial, is testing a structured intervention designed to achieve and sustain this over 2 years in a primary care setting to determine practicability for routine clinical practice. This paper reports the characteristics of the baseline cohort. People with type 2 diabetes for <6 years with a BMI of 27-45 kg/m2 were recruited in 49 UK primary care practices, randomised to either best-practice diabetes care alone or with an additional evidence-based weight management programme (Counterweight-Plus). The co-primary outcomes, at 12 months, are weight loss ≥15 kg and diabetes remission (HbA1c <48 mmol/mol [6.5%]) without glucose-lowering therapy for at least 2 months. Outcome assessors are blinded to group assignment. Of 1510 people invited, 423 (28%) accepted; of whom, 306 (72%) were eligible at screening and gave informed consent. Seven participants were later found to have been randomised in error and one withdrew consent, leaving 298 (176 men, 122 women) who will form the intention to treat (ITT) population for analysis. Mean (SD) age was 54.4 (7.6) years, duration of diabetes 3.0 (1.7) years, BMI 34.6 (4.4) kg/m2 for all participants (34.2 (4.2) kg/m2 in men and 35.3 (4.6) kg/m2 in women) and baseline HbA1c (on treatment) 59.3 (12.7) mmol/mol (7.6% [1.2%]). The recruitment rate in the intervention and control groups, and comparisons between the subgroups recruited in Scotland and England, showed few differences. DiRECT has recruited a cohort of people with type 2 diabetes with characteristics similar to those seen in routine practice, indicating potential widespread applicability. Over 25% of the eligible population wished to participate in the study, including a high proportion of men, in line with the prevalence distribution of type 2 diabetes. www.controlled-trials.com/ISRCTN03267836 ; date of registration 20 December 2013. |
X Demographics
The data shown below were collected from the profiles of 75 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 31 | 41% |
| France | 2 | 3% |
| South Africa | 1 | 1% |
| India | 1 | 1% |
| Japan | 1 | 1% |
| Australia | 1 | 1% |
| Brazil | 1 | 1% |
| Italy | 1 | 1% |
| Malta | 1 | 1% |
| Other | 8 | 11% |
| Unknown | 27 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 37 | 49% |
| Practitioners (doctors, other healthcare professionals) | 22 | 29% |
| Scientists | 15 | 20% |
| Unknown | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 201 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 29 | 14% |
| Researcher | 28 | 14% |
| Student > Bachelor | 27 | 13% |
| Student > Ph. D. Student | 19 | 9% |
| Other | 12 | 6% |
| Other | 26 | 13% |
| Unknown | 60 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 59 | 29% |
| Nursing and Health Professions | 28 | 14% |
| Biochemistry, Genetics and Molecular Biology | 9 | 4% |
| Psychology | 9 | 4% |
| Agricultural and Biological Sciences | 7 | 3% |
| Other | 22 | 11% |
| Unknown | 67 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2020.
All research outputs
#697,475
of 25,134,448 outputs
Outputs from Diabetologia
#357
of 5,321 outputs
Outputs of similar age
#15,784
of 450,285 outputs
Outputs of similar age from Diabetologia
#12
of 70 outputs
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