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Polyacrylate-Based Delivery System for Self-adjuvanting Anticancer Peptide Vaccine

Overview of attention for article published in Journal of Medicinal Chemistry, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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1 blog
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2 X users

Citations

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56 Dimensions

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44 Mendeley
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Title
Polyacrylate-Based Delivery System for Self-adjuvanting Anticancer Peptide Vaccine
Published in
Journal of Medicinal Chemistry, December 2014
DOI 10.1021/jm501514h
Pubmed ID
Authors

Tzu-Yu Liu, Waleed M. Hussein, Ashwini Kumar Giddam, Zhongfan Jia, Jennifer M. Reiman, Mehfuz Zaman, Nigel A. J. McMillan, Michael F. Good, Michael J. Monteiro, Istvan Toth, Mariusz Skwarczynski

Abstract

Vaccination can provide a safe alternative to chemotherapy by using the body's natural defense mechanisms to create a potent immune response against tumor cells. Peptide-based therapeutic vaccines against human papillomavirus (HPV)-related cancers are usually designed to elicit cytotoxic T cell responses by targeting the HPV-16 E7 oncoprotein. However, peptides alone lack immunogenicity and an additional adjuvant or external delivery system is required. In this study, we developed new polymer-peptide conjugates to create an efficient self-adjuvanting system for peptide-based therapeutic vaccines. These conjugates reduced tumor growth and eradicated E7-positive TC-1 tumors in mice after a "single shot" immunization, without the help from an external adjuvant. The new conjugates had a significantly higher anticancer efficacy than the antigen formulated with a commercial adjuvant. Furthermore, the polymer-peptide conjugates were promptly taken up by antigen presenting cells, including dendritic cells and macrophages, and efficiently activated CD4+ T-helper cells and CD8+ cytotoxic T lymphocyte cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
China 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 25%
Student > Master 6 14%
Researcher 6 14%
Student > Bachelor 4 9%
Other 4 9%
Other 6 14%
Unknown 7 16%
Readers by discipline Count As %
Chemistry 11 25%
Agricultural and Biological Sciences 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Chemical Engineering 4 9%
Engineering 3 7%
Other 6 14%
Unknown 11 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#4,070,929
of 24,629,540 outputs
Outputs from Journal of Medicinal Chemistry
#6,307
of 22,842 outputs
Outputs of similar age
#54,624
of 363,265 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#42
of 145 outputs
Altmetric has tracked 24,629,540 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,842 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.