Title |
Polyacrylate-Based Delivery System for Self-adjuvanting Anticancer Peptide Vaccine
|
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Published in |
Journal of Medicinal Chemistry, December 2014
|
DOI | 10.1021/jm501514h |
Pubmed ID | |
Authors |
Tzu-Yu Liu, Waleed M. Hussein, Ashwini Kumar Giddam, Zhongfan Jia, Jennifer M. Reiman, Mehfuz Zaman, Nigel A. J. McMillan, Michael F. Good, Michael J. Monteiro, Istvan Toth, Mariusz Skwarczynski |
Abstract |
Vaccination can provide a safe alternative to chemotherapy by using the body's natural defense mechanisms to create a potent immune response against tumor cells. Peptide-based therapeutic vaccines against human papillomavirus (HPV)-related cancers are usually designed to elicit cytotoxic T cell responses by targeting the HPV-16 E7 oncoprotein. However, peptides alone lack immunogenicity and an additional adjuvant or external delivery system is required. In this study, we developed new polymer-peptide conjugates to create an efficient self-adjuvanting system for peptide-based therapeutic vaccines. These conjugates reduced tumor growth and eradicated E7-positive TC-1 tumors in mice after a "single shot" immunization, without the help from an external adjuvant. The new conjugates had a significantly higher anticancer efficacy than the antigen formulated with a commercial adjuvant. Furthermore, the polymer-peptide conjugates were promptly taken up by antigen presenting cells, including dendritic cells and macrophages, and efficiently activated CD4+ T-helper cells and CD8+ cytotoxic T lymphocyte cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
China | 1 | 2% |
Unknown | 42 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 25% |
Student > Master | 6 | 14% |
Researcher | 6 | 14% |
Student > Bachelor | 4 | 9% |
Other | 4 | 9% |
Other | 6 | 14% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 11 | 25% |
Agricultural and Biological Sciences | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Chemical Engineering | 4 | 9% |
Engineering | 3 | 7% |
Other | 6 | 14% |
Unknown | 11 | 25% |